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Antagonists of vitamin B6. Simultaneous and stepwise modification of the 2 and 4 positions W. Korytnyk and P. G. G. Potti pp 1 - 5; DOI: 10.1021/jm00211a001 |
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Studies on vitamin D (calciferol) and its analogs. 10. Side-chain analogs of 25-hydroxyvitamin D3 R. Lorne Johnson, Stephen C. Carey, Anthony W. Norman, and William H. Okamura pp 5 - 11; DOI: 10.1021/jm00211a002 |
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Molecular conformation of ammonium 8-anilino-1-naphthalenesulfonate hemihydrate. A fluorescent probe for thyroxine binding to thyroxine binding globulin Vivian Cody and John Hazel pp 12 - 17; DOI: 10.1021/jm00211a003 |
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Cannabinoids. 1. 1-Amino- and 1-mercapto-7,8,9,10-tetrahydro-6H-dibenzo[b,d]pyrans Ken Matsumoto, Paul Stark, and Robert G. Meister pp 17 - 24; DOI: 10.1021/jm00211a004 |
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Cannabinoids. 2. Synthesis and central nervous system activities of some B-ring homocannabinoid derivatives and related lactones Ken Matsumoto, Paul Stark, and Robert G. Meister pp 25 - 30; DOI: 10.1021/jm00211a005 |
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Semisynthetic cephalosporins. Synthesis and structure-activity relations of analogs with 7-acyl groups derived from 2-(cyanomethylthio)acetic acid or 2-[(2,2,2-trifluoroethyl)thio]acetic acid and their sulfoxides and sulfones R. M. DeMarinis, J. C. Boehm, G. L. Dunn, J. R. E. Hoover, J. V. Uri, J. R. Guarini, L. Phillips, P. Actor, and J. A. Weisbach pp 30 - 35; DOI: 10.1021/jm00211a006 |
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11,12-Secoprostaglandins. 1. Acylhydroxyalkanoic acids and related compounds John B. Bicking, Charles M. Robb, Robert L. Smith, Edward J. Cragoe, Frederick A. Kuehl, and Lewis R. Mandel pp 35 - 43; DOI: 10.1021/jm00211a007 |
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11,12-Secoprostaglandins. 2. N-Acyl-N-alkyl-7-aminoheptanoic acids James H. Jones, Wilbur J. Holtz, John B. Bicking, Edward J. Cragoe, Lewis R. Mandel, and Frederick A. Kuehle pp 44 - 48; DOI: 10.1021/jm00211a008 |
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Structure-activity relation in cinnamamides. 2. Synthesis and pharmacological evaluation of some (E)- and (Z)-N-alkyl-.alpha.,.beta.-dimethylcinnamamides substituted on the phenyl group A. Balsamo, P. L. Barili, P. Crotti, B. Macchia, F. Macchia, A. Cuttica, and N. Passerini pp 48 - 53; DOI: 10.1021/jm00211a009 |
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Use of distribution coefficients in quantitative structure-activity relations Robert A. Scherrer and Susan M. Howard pp 53 - 58; DOI: 10.1021/jm00211a010 |
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Effect of sulfur substitution for the noncarbonyl oxygen in hemicholinium-3 and acetyl-seco-hemicholinium-3. Synthesis, biological activity, and structure-toxicity relations. 2 Floyd R. Domer, David M. Chihal, H. Cecil Charles, and Arvind B. Rege pp 59 - 62; DOI: 10.1021/jm00211a011 |
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5,11-Dimethyl-2,9-bis(phenylacetyl)-5,11-diazatetracyclo[6.2.2.02,7.04,9]dodecane, a potent, novel analgesic M. H. Fisher, E. J. J. Grabowski, A. A. Patchett, J. Ten Broeke, L. M. Flataker, V. J. Lotti, and F. M. Robinson pp 63 - 66; DOI: 10.1021/jm00211a012 |
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Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 1. 6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-acetic acids Daniel E. Aultz, Grover C. Helsley, David Hoffman, Arthur R. McFadden, Howard B. Lassman, and Jeffrey C. Wilker pp 66 - 70; DOI: 10.1021/jm00211a013 |
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Synthesis of mono- and bifunctional .alpha.-methylene lactone systems as potential tumor inhibitors Paul A. Grieco, J. A. Noguez, Yukio Masaki, K. Hiroi, M. Nishizawa, Andre Rosowsky, Selma Oppenheim, and Herbert Lazarus pp 71 - 76; DOI: 10.1021/jm00211a014 |
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Synthesis and kinetic evaluation of S- and N-substituted cysteinylglycines as inhibitors of glyoxalase I Philip A. Lyon and Robert Vince pp 77 - 80; DOI: 10.1021/jm00211a015 |
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Syntheses and antiinflammatory and hypnotic activity of 5-alkoxy-3-(N-substituted carbamoyl)-1-phenylpyrazoles. 4 Shoji Sugiura, Sachio Ohno, Osamu Ohtani, Kihachiro Izumi, Tadashi Kitamikado, Hajime Asai, Kazuo Kato, Mikio Hori, and Hajime Fujimura pp 80 - 85; DOI: 10.1021/jm00211a016 |
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Ergoline congeners as potential inhibitors of prolactin release. 3. Derivatives of 3-phenylpiperidine David B. Rusterholz, Charles F. Barfknecht, and James A. Clemens pp 85 - 88; DOI: 10.1021/jm00211a017 |
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Irreversible enzyme inhibitors. 200. Active-site directed inhibitors of deoxycytidine kinase A. David Ward and B. R. Baker pp 88 - 92; DOI: 10.1021/jm00211a018 |
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Quantitative structure-activity relations for 5-substituted 8-hydroxyquinolines as inhibitors of dental plaque Victor D. Warner, Joseph D. Musto, Jayant N. Sane, Ki Hwan Kim, and Gary L. Grunewald pp 92 - 96; DOI: 10.1021/jm00211a019 |
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Quantitative structure-activity relation of antimalarial and dihydrofolate reductase inhibition by quinazolines and 5-substituted benzyl-2,4-diaminopyrimidines Corwin Hansch, James Y. Fukunaga, Priscilla Y. C. Jow, and John B. Hynes pp 96 - 102; DOI: 10.1021/jm00211a020 |
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Conformational studies of a family of related antimalarial phenanthrene amino alcohols Gilda H. Loew and Robert Sahakian pp 103 - 106; DOI: 10.1021/jm00211a021 |
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Synthetic models of DNA complexes with antimalarial compounds. 2. The problem of guanine specificity in chloroquine binding J. Bolte, C. Demuynck, and J. Lhomme pp 106 - 113; DOI: 10.1021/jm00211a022 |
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Nucleosides. 102. Synthesis of some 3'-deoxy-3'-substituted arabinofuranosylpyrimidine nucleosides David H. Hollenberg, Kyoichi Watanabe, and Jack J. Fox pp 113 - 116; DOI: 10.1021/jm00211a023 |
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Analogs of 8-azainosine Robert D. Elliott and John A. Montgomery pp 116 - 120; DOI: 10.1021/jm00211a024 |
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Synthesis and some pharmacological properties of [4-threonine,7-glycine]oxytocin, [1-(L-2-hydroxy-3-mercaptopropanoic acid),4-threonine,7-glycine]oxytocin (hydroxy[thr4, gly7]oxytocin), and [7-glycine]oxytocin, peptides with high oxytocic-antidiuretic selectivity John Lowbridge, Maurice Manning, Jaya Haldar, and Wilbur H. Sawyer pp 120 - 123; DOI: 10.1021/jm00211a025 |
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2,3-Disubstituted 1,8-naphthyridines as potential diuretic agents Dennis K. J. Gorecki and Edward M. Hawes pp 124 - 128; DOI: 10.1021/jm00211a026 |
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Studies on anticoccidial agents. 10. Synthesis and anticoccidial activity of 5-nitronicotinamide and its analogs Yasuhiro Morisawa, Mitsuru Kataoka, Noritoshi Kitano, and Toshiaki Matsuzawa pp 129 - 133; DOI: 10.1021/jm00211a027 |
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Synthesis and antimicrobial activity of certain 6H-1,2,4-oxadiazin-3(2H)-ones Phillip T. Berkowitz, Robert A. Long, Phoebe Dea, Roland K. Robins, and Thomas R. Matthews pp 134 - 138; DOI: 10.1021/jm00211a028 |
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Mitomycin antibiotics. Synthesis and activity of 1,2-disubstituted mitosenes Wesley G. Taylor, Graham Leadbetter, Dennis L. Fost, and William A. Remers pp 138 - 141; DOI: 10.1021/jm00211a029 |
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Studies on antianaphylactic agents. 5. Synthesis of 3-(1H-tetrazol-5-yl)chromones, a new series of antiallergic substances Akira Nohara, Hisashi Kuriki, Taketoshi Saijo, Hirosada Sugihara, Morio Kanno, and Yasushi Sanno pp 141 - 145; DOI: 10.1021/jm00211a030 |
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Synthesis and identification of the major metabolites of prazosin formed in dog and rat T. H. Althuis and H. J. Hess pp 146 - 149; DOI: 10.1021/jm00211a031 |
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Synthesis and biological activity of some new furan quaternary salts Dilbagh R. Shridhar, Cherukuri V. Sastry, Sistla R. Moorty, Naresh K. Vaidya, Podduturu G. Reddy, Gopireddi S. Reddi, and Gurubachan S. Thapar pp 149 - 154; DOI: 10.1021/jm00211a032 |
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Synthesis and biological activity of .beta.-melanotropins and analogs Simon Lemaire, Donald Yamashiro, A. Jagannadha Rao, and Choh Hao Li pp 155 - 158; DOI: 10.1021/jm00211a033 |
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Syntheses and pharmacological activity of substituted imidazolidinethiones and thioimidazolines Harold Kohn, Barbara A. Kohn, Marie L. Steenberg, and Joseph P. Buckley pp 158 - 160; DOI: 10.1021/jm00211a034 |
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Inhibition of acetylcholinesterase by thiamine. A structure-function study Jonathan D. Alspach and Lloyd L. Ingraham pp 161 - 164; DOI: 10.1021/jm00211a035 |
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A rapid, high-yield conversion of codeine to morphine Kenner C. Rice pp 164 - 165; DOI: 10.1021/jm00211a036 |
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An improved method for O-demethylation of codeine J. A. Lawson and J. I. DeGraw pp 165 - 166; DOI: 10.1021/jm00211a037 |
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(2-Carboxy-1,4-dihydro-4-oxoquinolyl)oxamic acids and (2-carboxy-1,4-dihydro-4-oxobenzo[h]quinolyl)oxamic acids as antiallergy agents John B. Wright and Herbert G. Johnson pp 166 - 169; DOI: 10.1021/jm00211a038 |
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Synthesis and antiinflammatory activity of some 2-substituted 4- and 7-benzoxazoleacetic and .alpha.-methylacetic acids Delme Evans, Christine E. Smith, and W. R. Nigel Williamson pp 169 - 171; DOI: 10.1021/jm00211a039 |
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Butyrophenones from the isomeric 2-amino-5-phenylbicyclo[3.3.1]nonanes Daniel Lednicer pp 171 - 173; DOI: 10.1021/jm00211a040 |
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Synthesis of cephalosporin-4-aldehydes Philip J. Beeby pp 173 - 175; DOI: 10.1021/jm00211a041 |
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Model studies of pyridoxal Schiff's bases. Coplanarity and intramolecular hydrogen bonding Ching-Jer Chang, Tiee-Leou Shieh, and Heinz G. Floss pp 176 - 178; DOI: 10.1021/jm00211a042 |
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Structure-carcinogenic activity relations in the benz[a]anthracene series. 1,7,12- and 2,7,12-trimethylbenz[a]anthracenes Melvin S. Newman and William M. Hung pp 179 - 181; DOI: 10.1021/jm00211a043 |
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Book Reviews pp 181 - 184; DOI: 10.1021/jm00211a600 |
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In vitro stereoselective metabolism of the psychotomimetic amine, 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane. An apparent enantiomeric interaction N. Peter McGraw, Patrick S. Callery, and Neal Castagnoli pp 185 - 189; DOI: 10.1021/jm00212a001 |
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Aporphines. 21. Dopaminergic activity of aporphine and benzylisoquinoline derivatives. Synthesis of 8-hydroxyaporphines and 1-(hydroxybenzyl)-2-n-propyl-1,2,3,4-tetrahydroisoquinolines John L. Neumeyer, Werner P. Dafeldecker, Brenda Costall, and Robert J. Naylor pp 190 - 196; DOI: 10.1021/jm00212a002 |
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Synthesis and antitussive activity of aminotetra- (and -hexa-) hydrodibenzofurans Saroop S. Matharu, David A. Rowlands, John B. Taylor, and Robert Westwood pp 197 - 204; DOI: 10.1021/jm00212a003 |
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Synthesis and structure-activity relations of 5H,11H-[2]benzopyrano[4,3-g][1]benzopyran-9-carboxylic acids John P. Devlin, Kurt Freter, and P. Brian Stewart pp 205 - 209; DOI: 10.1021/jm00212a004 |
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Derivatives of tetrahydro-1,4-benzodiazepines as potential antihypertensive agents Dong Han Kim and Thomas Baum pp 209 - 212; DOI: 10.1021/jm00212a005 |
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Synthesis and topical antiinflammatory properties of 17,21-bis(acetyloxy)-6.beta.,9-difluoro-11.beta.-hydroxypregna-1,4-diene-3,20-dione and related 2-halogenated compounds Luciano Toscano, Giampiero Grisanti, Giuseppe Fioriello, Luigi Barlotti, Alberto Bianchetti, and Mario Riva pp 213 - 220; DOI: 10.1021/jm00212a006 |
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Azabicycloalkanes as analgetics. 3. Structure-activity relations of 1-phenyl-6-azabicyclo[3.2.1]octanes and absolute stereochemistry of (+)-1-(3-hydroxyphenyl)-6-methyl-6-azabicyclo[3.2.1]octane and its 7-endo-methyl derivative Mikio Takeda, Hirozumi Inoue, Katsuyuki Noguchi, Yasushi Honma, Masatoshi Kawamori, Goro Tsukamoto, Yasuhiko Yamawaki, Seiichi Saito, Keiichi Aoe, and et al. pp 221 - 228; DOI: 10.1021/jm00212a007 |
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Potential hypolipidemic agents derived from 3-hydroxy-17,17-dimethylgona-1,3,5(10),8,11,13-hexaene Leland J. Chinn and Karlene W. Salamon pp 229 - 233; DOI: 10.1021/jm00212a008 |
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p-Aminobenzoic acid derivatives as inhibitors of the cell-free H2-pteroate synthesizing system of Escherichia coli H. H. W. Thijssen pp 233 - 236; DOI: 10.1021/jm00212a009 |
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Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli Clara S. Genther and Carl C. Smith pp 237 - 243; DOI: 10.1021/jm00212a010 |
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Inhibition of squalene synthetase by farnesyl pyrophosphate analogs Paul R. Ortiz de Montellano, Jeng Shu Wei, Rafael Castillo, Charles K. Hsu, and Amrit Boparai pp 243 - 249; DOI: 10.1021/jm00212a011 |
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Inhibitors of polyamine biosynthesis. 4. Effects of .alpha.-methyl-(.+-.)-ornithine and methylglyoxal bis(guanylhydrazone) on growth and polyamine content of L1210 leukemic cells of mice Nancy E. Newton and Mahmoud M. Abdel-Monem pp 249 - 253; DOI: 10.1021/jm00212a012 |
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Synthesis of [1-sarcosine,8-O-methylserine]angiotensin II and 1-substituted analogs of [8-threonine]angiotensin II as antagonists of angiotensin II M. C. Khosla, M. M. Hall, H. Munoz-Ramirez, P. A. Khairallah, F M. Bumpus, J. H. Seely, and A. M. Thomas pp 253 - 256; DOI: 10.1021/jm00212a013 |
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Synthesis and antiviral activity of certain thiazole C-nucleosides Prem C. Srivastava, Michael V. Pickering, Lois B. Allen, David G. Streeter, Marie T. Campbell, Joseph T. Witkowski, Robert W. Sidwell, and Roland K. Robins pp 256 - 262; DOI: 10.1021/jm00212a014 |
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A study of the mechanism of halothane-induced liver necrosis. Role of covalent binding of halothane metabolites to liver proteins in the rat G. Subba Rao pp 262 - 265; DOI: 10.1021/jm00212a015 |
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2-Cyano-1,3-dicarbonyl compounds with antiallergic activity Derek R. Buckle, Barrie C. C. Cantello, Harry Smith, and Barbara A. Spicer pp 265 - 269; DOI: 10.1021/jm00212a016 |
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Antiarrhythmic activity of p-hydroxy-N-(2-diethylaminoethyl)benzamide (the p-hydroxy isostere of procainamide) in dogs and mice Dennis E. Drayer, Barry H. Slaven, Marcus M. Reidenberg, Ervin E. Bagwell, and Maria Cordova pp 270 - 274; DOI: 10.1021/jm00212a017 |
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Biological significance of the electronic structure of alloxan and its tautomers William Roy Hall pp 275 - 279; DOI: 10.1021/jm00212a018 |
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Synthesis of analogs of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents Thomas P. Johnston, George S. McCaleb, Sarah D. Clayton, Jerry L. Frye, Charles A. Krauth, and John A. Montgomery pp 279 - 290; DOI: 10.1021/jm00212a019 |
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Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma John A. Montgomery, George S. McCaleb, Thomas P. Johnston, Joseph G. Mayo, and W. Russell Laster pp 291 - 295; DOI: 10.1021/jm00212a020 |
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Synthesis and antifungal properties of certain 7-alkylaminopyrazolo[1,5-a]pyrimidines Thomas Novinson, Roland K. Robins, and Thomas R. Matthews pp 296 - 299; DOI: 10.1021/jm00212a021 |
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Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogs David E. Nichols and Donald C. Dyer pp 299 - 301; DOI: 10.1021/jm00212a022 |
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Esters of 4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazineethanol and related compounds as long-acting antipsychotic agents. Synthesis of the 1-adamantoate, the first crystalline base. 4 Harry L. Yale pp 302 - 304; DOI: 10.1021/jm00212a023 |
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Substituent constants for correlation analysis Corwin Hansch, Sharon D. Rockwell, Priscilla Y. C. Jow, Albert Leo, and Edward E. Steller pp 304 - 306; DOI: 10.1021/jm00212a024 |
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Synthesis and structure-activity relation studies of cytotoxic epoxide derivatives of 7-oxabicyclo[2.2.1]heptane Wayne K. Anderson and Richard H. Dewey pp 306 - 308; DOI: 10.1021/jm00212a025 |
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Relations between opiate receptor binding and analgetic properties of prodine-type compounds M. A. Iorio and W. A. Klee pp 309 - 310; DOI: 10.1021/jm00212a026 |
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9-Hydroxy-1,2,3,4,5,6-hexahydro-1,5-methano-3-benzazocine derivatives as analgesics Shunsaku Shiotani, Tadashi Kometani, and Kemmotsu Mitsuhashi pp 310 - 312; DOI: 10.1021/jm00212a027 |
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Synthesis and inhibition analysis of 2(4)-imino-4(2)-amino-2,4-dideoxyriboflavin, a dual antagonist of riboflavin and folinic acid C. K. Chu and T. J. Bardos pp 312 - 314; DOI: 10.1021/jm00212a028 |
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Synthesis and specific pressor activity of [1-aspartic acid, 5-valine, 9-serine]angiotensin I ("fowl and angiotensin I") M. C. Khosla, F. M. Bumpus, Y. Hayashi, T. Nakajima, T. X. Watanabe, and H. Sokabe pp 315 - 316; DOI: 10.1021/jm00212a029 |
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6-Aminopyrazolo[4,3-c]pyridin-4(5H)-one, a novel analog of guanine Kenneth W. Ehler, Roland K. Robins, and Rich B. Meyer pp 317 - 318; DOI: 10.1021/jm00212a030 |
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Estrogen potentiating activity of two spiro compounds having approximately similar molecular dimensions to stilbestrol Neil S. Doggett, David J. Bailey, and Tariq Qazi pp 318 - 320; DOI: 10.1021/jm00212a031 |
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A novel prostaglandin endoperoxide mimic, prostaglandin F2.alpha. acetal Philip S. Portoghese, Dennis L. Larson, Anthony G. Abatjoglou, Earl W. Dunham, Jonathan M. Gerrard, and James G. White pp 320 - 321; DOI: 10.1021/jm00212a032 |
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Book Reviews pp 321 - 324; DOI: 10.1021/jm00212a600 |
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Synthesis and analgesic activity of human .beta.-endorphin Choh Hao Li, Donald Yamashiro, Liang-Fu Tseng, and Horace H. Loh pp 325 - 328; DOI: 10.1021/jm00213a001 |
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Synthesis of cephalotaxine esters and correlation of their structures with antitumor activity Kenneth L. Mikolajczak, Cecil R. Smith, and David Weisleder pp 328 - 332; DOI: 10.1021/jm00213a002 |
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Antitumor agents. 21. A proposed mechanism for inhibition of cancer growth by tenulin and helenalin and related cyclopentenones Iris H. Hall, Kuo-Hsiung Lee, Eng Chun Mar, Charles O. Starnes, and Thomas G. Waddell pp 333 - 337; DOI: 10.1021/jm00213a003 |
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Pyrimidinylpropenamides as antitumor agents. Analogs of the antibiotic sparsomycin Chie-Chang L. Lin and Ronald J. Dubois pp 337 - 341; DOI: 10.1021/jm00213a004 |
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Potential antitumor agents. Some sulfur-substituted derivatives of .alpha.- and .beta.-2'-deoxythioguanosine Abelardo P. Martinez, William W. Lee, and David W. Henry pp 341 - 344; DOI: 10.1021/jm00213a005 |
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Fluorinated pyrimidine nucleosides. 1. Synthesis of a nitrogen analog of the antitumor agent 2,2'-anhydro-1-.beta.-D-arabinofuranosyl-5-fluorocytosine hydrochloride Alan F. Cook pp 344 - 348; DOI: 10.1021/jm00213a006 |
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Isolation, synthesis, and biological activity of five metabolites of danazol D. Rosi, H. C. Neumann, R. G. Christiansen, H. P. Schane, and G. O. Potts pp 349 - 352; DOI: 10.1021/jm00213a007 |
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Ring D oxygenated spirolactones. Characterization of a human metabolic product of spironolactone Leland J. Chinn, Edward A. Brown, Seth S. Mizuba, and Aziz Karim pp 352 - 355; DOI: 10.1021/jm00213a008 |
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Uptake and fate of water-soluble, nondegradable polymers with antiviral activity in cells and animals Lalita Noronha-Blob, Vitolis E. Vengris, Paula M. Pitha, and Josef Pitha pp 356 - 359; DOI: 10.1021/jm00213a009 |
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Disteroidyl ethers. 1. Synthesis and oral long-lasting uterotrophic activity of 1,3,5(10)-estratrien-17-yl enol ethers of 3-ketosteroids Romano Vitali, Serafino Gladiali, Giovanni Falconi, Giuseppe Celasco, Maria A. Saccani, and Rinaldo Gardi pp 359 - 364; DOI: 10.1021/jm00213a010 |
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Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 8. Bis-basic derivatives of carbazole, dibenzofuran, and dibenzothiophene William L. Albrecht, Robert W. Fleming, Stephen W. Horgan, and Gerald D. Mayer pp 364 - 371; DOI: 10.1021/jm00213a011 |
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Antagonists of slow reacting substance of anaphylaxis. Synthesis of a series of chromone-2-carboxylic acids R. A. Appleton, J. R. Bantick, T. R. Chamberlain, D. N. Hardern, T. B. Lee, and A. D. Pratt pp 371 - 379; DOI: 10.1021/jm00213a012 |
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Synthesis and central nervous system activity of quinazolones related to 2-methyl-3-(o-tolyl)-4(3H)-quinazolone (methaqualone) I. R. Ager, D. R. Harrison, P. D. Kennewell, and J. B. Taylor pp 379 - 386; DOI: 10.1021/jm00213a013 |
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3-Halo-5,7-dimethylpyrazolo[1,5-A]pyrimidines, a nonbenzodiazepinoid class of antianxiety agents devoid of potentiation of central nervous system depressant effects of ethanol or barbiturates William E. Kirkpatrick, Takayuki Okabe, Ira W. Hillyard, Roland K. Robins, Anthony T. Dren, and Thomas Novinson pp 386 - 393; DOI: 10.1021/jm00213a014 |
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Synthesis and adrenergic .beta.-blocking activity of some 1,3-benzodioxole derivatives Hideko Tatsuno, Katsutoshi Goto, Koki Shigenobu, Yutaka Kasuya, Hiroyuki Obase, Yoshiuki Yamada, and Shiro Kudo pp 394 - 397; DOI: 10.1021/jm00213a015 |
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Cholinergic compounds. 9. Cyclohexane analogs of deoxamuscarine and derivatives Piero Angeli, Carlo Melchiorre, Mario Giannella, Maria Pigini, and M. L. Cingolani pp 398 - 400; DOI: 10.1021/jm00213a016 |
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2-Substituted derivatives of 9-.alpha.-D-arabinofuranosyladenine and 9-.alpha.-D-arabinofuranosyl-8-azaadenine John A. Montgomery, Anita T. Shortnacy, G. Arnett, and W. M. Shannon pp 401 - 404; DOI: 10.1021/jm00213a017 |
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Potential long-acting anticonvulsants. 1. Synthesis and activity of succinimides containing an alkylating group at the 2 position Milton J. Kornet, A. Michael Crider, and Edward O. Magarian pp 405 - 409; DOI: 10.1021/jm00213a018 |
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Alkaloids of Vinca rosea L. (Catharanthus roseus G. Don). 38. 4'-Dehydrated derivatives Jean C. Miller, Gerald E. Gutowski, Gerald A. Poore, and George B. Boder pp 409 - 413; DOI: 10.1021/jm00213a019 |
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In vitro O-demethylation of the psychotomimetic amine, 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane Jonathan S. Zweig and Neal Castagnoli pp 414 - 421; DOI: 10.1021/jm00213a020 |
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2-, 3-, and 4-(.alpha.,.alpha.,.beta.,.beta.-Tetrafluorophenethyl)benzylamines. A new class of antiarrhythmic agents Marcia E. Christy, C. Dylion Colton, Mary Mackay, William H. Staas, Julia B. Wong, Edward L. Engelhardt, Mary L. Torchiana, and Clement A. Stone pp 421 - 430; DOI: 10.1021/jm00213a021 |
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Quantitative correlations between albumin binding constants and chromatographic RM values of phenothiazine derivatives Abram Hulshoff and John H. Perrin pp 430 - 439; DOI: 10.1021/jm00213a022 |
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p-Aminobenzoic acid derivatives. Mode of action and structure-activity relations in a cell-free system (Escherichia coli) J. K. Seydel and W. Butte pp 439 - 447; DOI: 10.1021/jm00213a023 |
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Elucidation of the structure of the antineoplastic agents, 2-formylpyridine and 1-formylisoquinoline thiosemicarbazones Ippolito Antonini, Francesco Claudi, Palmarisa Franchetti, Mario Grifantini, and Sante Martelli pp 447 - 449; DOI: 10.1021/jm00213a024 |
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Synthesis and antihypertensive activity of 1-amino-3,4-dihydroisoquinolines Guy D. Diana, W. Banks Hinshaw, and Harlan E. Lape pp 449 - 452; DOI: 10.1021/jm00213a025 |
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Synthesis and biological activity of potential antimetabolites G. I. Glover, S. O. Nelson, and G. R. Kaeder pp 452 - 453; DOI: 10.1021/jm00213a026 |
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Narcotic antagonists. Synthesis and evaluation of some substituted 1,2,3,4,5,6-hexahydro-1,4:2,6-dimethano-3-benzazocines Thomas A. Montzka and John D. Matiskella pp 453 - 456; DOI: 10.1021/jm00213a027 |
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Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 2. Dihydro-10-oxofuro- and -thieno[3,2-c][1]benzoxepin-8-acetic acids Daniel E. Aultz, Arthur R. McFadden, and Howard B. Lassman pp 456 - 458; DOI: 10.1021/jm00213a028 |
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Synthesis and antitumor activity of 1,2-dihydro-1-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-2-oxo-5-methylpyrazine 4-oxide, a structural analog of thymidine M. Bobek, A. Bloch, P. Berkowitz, and T. J. Bardos pp 458 - 460; DOI: 10.1021/jm00213a029 |
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Book Reviews pp 461 - 462; DOI: 10.1021/jm00213a600 |
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A manual method for applying the Hansch approach to drug design John G. Topliss pp 463 - 469; DOI: 10.1021/jm00214a001 |
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A statistical-heuristic method for automated selection of drugs for screening Louis Hodes, George F. Hazard, Ruth I. Geran, and Sidney Richman pp 469 - 475; DOI: 10.1021/jm00214a002 |
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Anticoccidial derivatives of 6-azauracil. 1. Enhancement of activity by benzylation of nitrogen-1. Observations on the design of nucleotide analogs in chemotherapy Banavara L. Mylari, Max W. Miller, Harold L. Howes, Sanford K. Figdor, John E. Lynch, and Richard C. Koch pp 475 - 483; DOI: 10.1021/jm00214a003 |
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Studies on anticoccidial agents. 11. Synthesis and anticoccidial activity of nitropyridinecarboxamides and derivatives Yasuhiro Morisawa, Mitsuru Kataoka, and Noritoshi Kitano pp 483 - 487; DOI: 10.1021/jm00214a004 |
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3-Aminotetrahydrocarbazoles as a new series of central nervous system agents Aram Mooradian, Paul E. Dupont, Allan G. Hlavac, Mario D. Aceto, and Jack Pearl pp 487 - 492; DOI: 10.1021/jm00214a005 |
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Combined high oxytocic with negligible antidiuretic and pressor activities in multisubstituted oxytocins Glenn L. Stahl and Roderich Walter pp 492 - 495; DOI: 10.1021/jm00214a006 |
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Pharmacological effects of introducing a double bond into a binding site of oxytocin. Analogs with L-3,4-dehydroproline in position 7 Stanley Moore, Arthur M. Felix, Johannes Meienhofer, Clark W. Smith, and Roderich Walter pp 495 - 500; DOI: 10.1021/jm00214a007 |
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Polyamine biosynthesis in rat prostate. Substrate and inhibitor properties of 7-deaza analogs of decarboxylated S-adenosylmethionine and 5'-methylthioadenosine James K. Coward, Nancy C. Motola, and James D. Moyer pp 500 - 505; DOI: 10.1021/jm00214a008 |
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Inhibition of histidine decarboxylase. Derivatives of histidine James L. Kelley, Carl A. Miller, and Helen L. White pp 506 - 509; DOI: 10.1021/jm00214a009 |
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Synthesis and structure-activity relations of bestatin analogs, inhibitors of aminopeptidase B Rinzo Nishizawa, Tetsushi Saino, Tomohisa Takita, Hiroyuki Suda, Takaaki Aoyagi, and Hamao Umezawa pp 510 - 515; DOI: 10.1021/jm00214a010 |
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Potential antitumor agents. 21. Dialkanolamine dialkanesulfonic esters Bruce F. Cain and William A. Denny pp 515 - 520; DOI: 10.1021/jm00214a011 |
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Potential antitumor agents. 22. Latentiated congeners of the 4'-(9-acridinylamino)methanesulfonanilides Graham J. Atwell, Bruce F. Cain, and William A. Denny pp 520 - 526; DOI: 10.1021/jm00214a012 |
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.beta.-Adrenoceptor studies. 2. Effects of alkyl substitution on .beta.-adrenoceptor blocking, antiarrhythmic, and local anesthetic activities of 1,1'-(o-phenylenedioxy)bis(3-isopropylamino-2-propanol) Johan Zaagsma and Wijbe T. Nauta pp 527 - 531; DOI: 10.1021/jm00214a013 |
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Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)furans Bijan P. Das and David W. Boykin pp 531 - 536; DOI: 10.1021/jm00214a014 |
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Experimental antiulcer drugs. 1. Indole-1-alkanamides and pyrrole-1-alkanamides Malcolm R. Bell, Andrew W. Zalay, Rudolf Oesterlin, Stephen D. Clemans, Donald J. Dumas, James C. Bradford, and Janis Rozitis pp 537 - 540; DOI: 10.1021/jm00214a015 |
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11,12-Secoprostaglandins. 3. 8-Alkylthio(sulfinyl and sulfonyl)-12-hydroxyalkanoic acids and related compounds Robert L. Smith, John B. Bicking, Norman P. Gould, Ta-Jyh Lee, Charles M. Robb, Frederick A. Kuehl, Lewis R. Mandel, and Edward J. Cragoe pp 540 - 547; DOI: 10.1021/jm00214a016 |
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Synthesis, antifertility activity, and protein binding affinity of 7(8 .fwdarw. 11.alpha.)abeo steroids Mansukh C. Wani, Douglas H. Rector, David H. White, Colin G. Pitt, and Gary L. Kimmel pp 547 - 551; DOI: 10.1021/jm00214a017 |
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Total synthesis of (.+-.)-1-carbacefoxitin and -cefamandole and (.+-.)-1-oxacefamandole Raymond A. Firestone, John L. Fahey, Natalie S. Maciejewicz, Gool S. Patel, and B. G. Christensen pp 551 - 556; DOI: 10.1021/jm00214a018 |
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Nitrones. 7. .alpha.-Quinoxalinyl-N-substituted nitrone 1,4-dioxides Hyun K. Kim, Laird F. Miller, Ronald E. Bambury, and Harry W. Ritter pp 557 - 560; DOI: 10.1021/jm00214a019 |
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.beta.-Lactam antibiotics derived from nitrogen hetrocyclic acetic acids. 1. Penicillin derivatives M. L. Edwards, R. E. Bambury, and H. W. Ritter pp 560 - 563; DOI: 10.1021/jm00214a020 |
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Tetramisole analogs as inhibitors of alkaline phosphatase, an enzyme involved in the resistance of neoplastic cells to 6-thiopurines Kuldeep K. Bhargava, Men H. Lee, Yow-Mei Huang, Linda S. Cunningham, Krishna C. Agrawal, and Alan C. Sartorelli pp 563 - 566; DOI: 10.1021/jm00214a021 |
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4-Halovinyl- and 4-ethynyl-4-deformylpyridoxal derivatives and related analogs as potentially irreversible antagonists of vitamin B6 W. Korytnyk and P. G. G. Potti pp 567 - 572; DOI: 10.1021/jm00214a022 |
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Mercapto heterocyclic carboxylic acids, analogs of 3-mercaptopicolinic acid Benjamin Blank, Nicholas W. DiTullio, Franklin F. Owings, Linda Deviney, Clara K. Miao, and Harry L. Saunders pp 572 - 576; DOI: 10.1021/jm00214a023 |
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Synthesis and hypoglycemic activity of S-acyl derivatives of 3-mercaptopicolinic acid Benjamin Blank, Nicholas W. DiTullio, Linda Deviney, John T. Roberts, and Harry L. Saunders pp 577 - 579; DOI: 10.1021/jm00214a024 |
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Relative concentrations of zwitterionic and uncharged species in catecholamines and the effect of N-substituents C. Robin Ganellin pp 579 - 581; DOI: 10.1021/jm00214a025 |
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Isolation and identification of an in vivo reaction product of 6-hydroxydopamine Y. O. Liang, P. M. Plotsky, and R. N. Adams pp 581 - 583; DOI: 10.1021/jm00214a026 |
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Correction of prior estimate of the biological activity of an N-trifluoroacetyl analog of D-threo-chloramphenicol relative to chloramphenicol Edward R. Garrett pp 583 - 584; DOI: 10.1021/jm00214a027 |
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Evidence for separate peptide sequences related to the lipolytic and magnesium-accumulating activities of ACTH. Analogy with adrenergic receptors Donald A. Elliott, Michael W. Draper, and Martin A. Rizack pp 584 - 586; DOI: 10.1021/jm00214a028 |
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Quantitative structure-activity relations of chymotrypsin. The predictive value of correlation equations Ciro Grieco, Carlo Silipo, Antonio Vittoria, and Corwin Hansch pp 586 - 588; DOI: 10.1021/jm00214a029 |
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Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogs of folic and isofolic acids John B. Hynes, Donald E. Eason, Claudia M. Garrett, Perry L. Colvin, Kenneth E. Shores, and James H. Freisheim pp 588 - 591; DOI: 10.1021/jm00214a030 |
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Hydantoins as antitumor agents Thomas R. Rodgers, Maurice P. LaMontagne, Anica Markovac, and Arthur B. Ash pp 591 - 594; DOI: 10.1021/jm00214a031 |
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Antiallergic agents. Xanthone-2,7-dicarboxylic acid derivatives Winton D. Jones, William L. Albrecht, Nancy L. Munro, and Kenneth T. Stewart pp 594 - 595; DOI: 10.1021/jm00214a032 |
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Antiinflammatory activity of isomeric phenylnaphthaleneacetic acids James S. Kaltenbronn pp 596 - 598; DOI: 10.1021/jm00214a033 |
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Synthesis of 5-azacytidine-6-13C and -6-14C Kenneth K. Chan, James A. Staroscik, and Wolfgang Sadee pp 598 - 600; DOI: 10.1021/jm00214a034 |
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Synthesis of some conformationally restricted analogs of fentanyl Joel G. Berger, Fredric Davidson, and Gordon E. Langford pp 600 - 602; DOI: 10.1021/jm00214a035 |
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Synthesis of some pentazocine metabolites and related compounds Noel F. Albertson and Frank C. McKay pp 602 - 604; DOI: 10.1021/jm00214a036 |
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In vitro metabolism of a new 4-hydroxycoumarin anticoagulant. Structure of an unusual metabolite Nadine Thonnart, Maurice Vanhaelen, and Renee Vanhaelen-Fastre pp 604 - 606; DOI: 10.1021/jm00214a037 |
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Antifungal properties of 2-bromo-3-fluorosuccinic acid esters and related compounds Herman Gershon and Larry Shanks pp 606 - 609; DOI: 10.1021/jm00214a038 |
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Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines as potential central nervous system agents. 2. Compounds containing a heteroatom attached to nitrogen Solomon S. Klioze, Victor J. Bauer, and Harry M. Geyer pp 610 - 612; DOI: 10.1021/jm00214a039 |
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Carbocyclic arabinosyladenine, an adenosine deaminase resistant antiviral agent Robert Vince and Susan Daluge pp 612 - 613; DOI: 10.1021/jm00214a040 |
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Book Reviews pp 614 - 618; DOI: 10.1021/jm00214a600 |
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Theory of linear equations as applied to quantitative structure-activity correlations L. J. Schaad and B. A. Hess pp 619 - 625; DOI: 10.1021/jm00215a001 |
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Quantitative structure-activity relations. 7. The bilinear model, a new model for nonlinear dependence of biological activity on hydrophobic character Hugo Kubinyi pp 625 - 629; DOI: 10.1021/jm00215a002 |
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Study of trans-cyclopropylbis(diketopiperazine) and chelating agents related to ICRF 159. Cytotoxicity, mutagenicity, and effects on scheduled and unscheduled DNA synthesis Donald T. Witiak, Hee J. Lee, Ronald W. Hart, and Ruth E. Gibson pp 630 - 635; DOI: 10.1021/jm00215a003 |
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Nonenolizable podophyllotoxin derivatives Walter J. Gensler, C. D. Murthy, and Marion H. Trammell pp 635 - 644; DOI: 10.1021/jm00215a004 |
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3-Fluoro-1-hydroxypropan-2-one (fluorohydroxyacetone) and some esters. Syntheses and effects in BDF1 mice Richard W. Pero, Paula Babiarz-Tracy, and Thomas P. Fondy pp 644 - 647; DOI: 10.1021/jm00215a005 |
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Synthesis of phenolic group containing analogs of porcine secretin and their immunological properties Noboru Yanaihara, Mari Kubota, Masanori Sakagami, Haruko Sato, Tohru Mochizuki, Naoki Sakura, Tadashi Hashimoto, Chizuko Yanaihara, Ken Yamaguchi, and et al. pp 648 - 655; DOI: 10.1021/jm00215a006 |
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Synthesis and biological activity of some vinyl-substituted 2-nitroimidazoles Bruno Cavalleri, Giancarlo Volpe, and Vittorio Arioli pp 656 - 660; DOI: 10.1021/jm00215a007 |
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Synthesis and anti-herpes simplex activity of analogs of phosphonoacetic acid Thomas R. Herrin, John S. Fairgrieve, Robert R. Bower, Nathan L. Shipkowitz, and James C. H. Mao pp 660 - 663; DOI: 10.1021/jm00215a008 |
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Synthesis and antimicrobial activity of azasteroid-type compounds and related systems. Effect of hydrophilic and lipophilic groups on activity K. Ramalingam, Larry F. Wong, K. Darrell Berlin, Rebecca A. Brown, Randy Fischer, Jim Blunk, and N. N. Durham pp 664 - 669; DOI: 10.1021/jm00215a009 |
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Thymidylate synthetase inhibitors. Synthesis of N-substituted 5-aminomethyl-2'-deoxyuridine 5'-phosphates Marshall S. Edelman, Roxane L. Barfknecht, Rocio Huet-Rose, Sophie Boguslawski, and Mathias P. Mertes pp 669 - 673; DOI: 10.1021/jm00215a010 |
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N-(2,4,5-Trihydroxyphenethyl)normetazocine, a potential irreversible inhibitor of the narcotic receptor Kenner C. Rice, Shunsaku Shiotani, Cyrus R. Creveling, Arthur E. Jacobson, and Werner A. Klee pp 673 - 675; DOI: 10.1021/jm00215a011 |
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5-Allyl-9-oxobenzomorphans. 3. Potent narcotic antagonists and analgesics-antagonists in the series of substituted 2',9.beta.-dihydroxy-6,7-benzomorphans Michel Saucier, Jean Paul Daris, Yvon Lambert, Ivo Monkovic, and Anthony W. Pircio pp 676 - 682; DOI: 10.1021/jm00215a012 |
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Synthesis and narcotic agonist-antagonist evaluation of some 2,6-methano-3-benzazocine-11-propanols. Analogs of the ring C bridged oripavine-7-methanols William F. Michne, Ronald L. Salsbury, and Stephen J. Michalec pp 682 - 686; DOI: 10.1021/jm00215a013 |
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Adrenergic agents. 4. Substituted phenoxypropanolamine derivatives as potential .beta.-adrenergic agonists Carl Kaiser, Timothy Jen, Eleanor Garvey, Wayne D. Bowen, Donald F. Colella, and Joe R. Wardell pp 687 - 692; DOI: 10.1021/jm00215a014 |
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Adrenergic agents. 5. Conformational analysis of 1-alkylamino-3-aryloxy-2-propanols by proton magnetic resonance studies. Implications relating to the steric requirements of adrenoreceptors Timothy Jen and Carl Kaiser pp 693 - 698; DOI: 10.1021/jm00215a015 |
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Analgesic and tranquilizing activity of 5,8-disubstituted 1-tetralone Mannich bases Willard M. Welch, Charles A. Harbert, Reinhard Sarges, Wilford P. Stratten, and Albert Weissman pp 699 - 705; DOI: 10.1021/jm00215a016 |
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.beta.-Adrenergic blocking agents. 15. 1-Substituted ureidophenoxy-3-amino-2-propanols L. H. Smith pp 705 - 708; DOI: 10.1021/jm00215a017 |
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Nonsteroidal antiinflammatory agents. 1. 5-Alkoxy-3-biphenylylacetic acids and related compounds as new potential antiinflammatory agents Yasumitsu Tamura, Yoshihiko Yoshimoto, Katsutoshi Kunimoto, Shinichi Tada, Toshio Tomita, Toshiyuki Wada, Eisuke Seto, Masao Murayama, Yoshihisa Shibata, and et al. pp 709 - 714; DOI: 10.1021/jm00215a018 |
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5,6,7,8-Tetrahydroquinolines. 4. Antiulcer and antisecretory activity of 5,6,7,8-tetrahydroquinolinenitriles and -thioamides Doreen E. Beattie, Roger Crossley, Adrian C. W. Curran, Geoffrey T. Dixon, David G. Hill, Anne E. Lawrence, and Robin G. Shepherd pp 714 - 718; DOI: 10.1021/jm00215a019 |
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5,6,7,8-Tetrahydroquinolines. 5. Antiulcer and antisecretory activity of 5,6,7,8-tetrahydroquinolinethioureas and related heterocycles Doreen E. Beattie, Roger Crossley, Adrian C. W. Curran, David G. Hill, and Anne E. Lawrence pp 718 - 721; DOI: 10.1021/jm00215a020 |
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Attempted inhibition of histidine decarboxylase with .beta.-alkyl analogs of histidine James L. Kelley, Carl A. Miller, and Ed W. McLean pp 721 - 723; DOI: 10.1021/jm00215a021 |
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3-Aryl-as-triazines as potential antiinflammatory agents M. O'Rourke, S. A. Lang, and E. Cohen pp 723 - 726; DOI: 10.1021/jm00215a022 |
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Synthesis and antiinflammatory activity of cis-4,5,6,7,8,8a,9-hexahydro-.alpha.-methyl-5H-fluorene-2-acetic acid P. W. Sprague and J. E. Heikes pp 726 - 728; DOI: 10.1021/jm00215a023 |
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Synthesis and central nervous system activity of 2-arylidene-4-aminoalkyl-2H-1,4-benzoxazin-3(4H)-ones and related compounds Chester F. Turk, John Krapcho, I. M. Michel, and I. Weinryb pp 729 - 732; DOI: 10.1021/jm00215a024 |
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Structure-activity relations among the O-acyl derivatives of leucomycin. Correlation of minimal inhibitory concentrations with binding to Escherichia coli ribosomes S. Omura, A. Nakagawa, H. Sakakibara, O. Okekawa, R. Brandsch, and S. Pestka pp 732 - 736; DOI: 10.1021/jm00215a025 |
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Book Reviews pp 736 - 740; DOI: 10.1021/jm00215a600 |
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In search of anti-Trypanosoma cruzi drugs: new leads from a mouse model Kenneth E. Kinnamon, Edgar A. Steck, William L. Hanson, and Willie L. Chapman pp 741 - 744; DOI: 10.1021/jm00216a001 |
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Vitamin B6 antagonists obtained by replacing or modifying the 2-methyl group W. Korytnyk and N. Angelino pp 745 - 749; DOI: 10.1021/jm00216a002 |
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Antiviral activity of some .beta.-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses Guy D. Diana, U. Joseph Salvador, Ethel S. Zalay, Robert E. Johnson, Joseph C. Collins, David Johnson, William B. Hinshaw, Roman R. Lorenz, William H. Thielking, and Francis Pancic pp 750 - 756; DOI: 10.1021/jm00216a003 |
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Antiviral activity of some .beta.-diketones. 2. Aryloxy alkyl diketones. In vitro activity against both RNA and DNA viruses Guy D. Diana, U. Joseph Salvador, Ethel S. Zalay, Philip M. Carabateas, Gordon L. Williams, Joseph C. Collins, and Francis Pancic pp 757 - 761; DOI: 10.1021/jm00216a004 |
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New inhibitors of steroid 11.beta.-hydroxylase. Structure-activity relation studies of metyrapone-like compounds Joseph L. Napoli and Raymond E. Counsell pp 762 - 766; DOI: 10.1021/jm00216a005 |
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Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene Leung Cheng and William A. Remers pp 767 - 770; DOI: 10.1021/jm00216a006 |
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Conformational analogs of antihypertensive agents related to guanethidine R. F. Borne, M. L. Forrester, and I. W. Waters pp 771 - 776; DOI: 10.1021/jm00216a007 |
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5-Aryl-1,5-dihydro-2H-1,4-benzodiazepin-2-one derivatives as antianxiety agents Masaru Ogata, Hiroshi Matsumoto, and Katsumi Hirose pp 776 - 781; DOI: 10.1021/jm00216a008 |
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5-(Tetradecyloxy)-2-furancarboxylic acid and related hypolipidemic fatty acid-like alkyloxyarylcarboxylic acids Roger A. Parker, Takashi Kariya, J. Martin Grisar, and Vladimir Petrow pp 781 - 791; DOI: 10.1021/jm00216a009 |
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Studies on quinoline derivatives and related compounds. 5. Synthesis and antimicrobial activity of novel 1-alkoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids Hideo Agui, Tohru Mitani, Akio Izawa, Toshiaki Komatsu, and Takenari Nakagome pp 791 - 796; DOI: 10.1021/jm00216a010 |
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Synthesis and antiinflammatory activity of some 2-aryl-6-benzoxazoleacetic acid derivatives David W. Dunwell and Delme Evans pp 797 - 801; DOI: 10.1021/jm00216a011 |
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3,4-Methylenedioxyphenyl-, isopropylidenedioxyphenyl-, and benzyl-substituted chiral 2-aminosuccinimides and 3-aminopyrrolidines. Stereoselective investigations of potential anti-Parkinsonian, antipsychotic, and anticonvulsant activities Donald T. Witiak, Babu R. Vishnuvajjala, Wayne L. Cook, John A. Minatelli, Tribhuwan K. Gupta, and Michael C. Gerald pp 801 - 805; DOI: 10.1021/jm00216a012 |
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Synthesis and antitumor activity of dihydro-5-azacytidine, a hydrolytically stable analog of 5-azacytidine John A. Beisler, Mohamed M. Abbasi, James A. Kelley, and John S. Driscoll pp 806 - 812; DOI: 10.1021/jm00216a013 |
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Synthesis and antileukemic activity of 5-substituted 2,3-dihydro-6,7-bis(hydroxymethyl)-1H-pyrrolizine diesters Wayne K. Anderson and Paul F. Corey pp 812 - 818; DOI: 10.1021/jm00216a014 |
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Synthesis and biochemical evaluation of nucleosides of naphthoquinone heterocycles Michael V. Pickering, Phoebe Dea, David G. Streeter, and Joseph T. Witkowski pp 818 - 821; DOI: 10.1021/jm00216a015 |
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Antiarrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides E. H. Banitt, W. R. Bronn, W. E. Coyne, and J. R. Schmid pp 821 - 826; DOI: 10.1021/jm00216a016 |
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Synthesis of 5-chloro-3'-nitro-4'-substituted salicylanilides, a new series of anthelmintic and antimicrobial agents Harindra Singh, A. K. Singh, Satyavan Sharma, R. N. Iyer, and O. P. Srivastava pp 826 - 829; DOI: 10.1021/jm00216a017 |
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Imidazo[4,5-f]quinolines. 2. A series of 9-(substituted amino)imidazo[4,5-f]quinolines as antitapeworm agents Claude F. Spencer, Harry R. Snyder, Homer A. Burch, and Christopher J. Hatton pp 829 - 833; DOI: 10.1021/jm00216a018 |
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Synthesis of medroxyprogesterone bromoacetate for affinity labeling Bhaskar R. Samant and Frederick Sweet pp 833 - 835; DOI: 10.1021/jm00216a019 |
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A comparison of the antiserotonin, antihistamine, and anticholinergic activity of cyproheptadine with analogs having furan nuclei fused to the 10,11-vinylene bridge David C. Remy, Andrew W. Raab, Kenneth E. Rittle, Edward L. Engelhardt, Alexander Scriabine, and Victor J. Lotti pp 836 - 838; DOI: 10.1021/jm00216a020 |
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2,3-Disubstituted 1,8-naphthyridines as potential diuretic agents. 2. 5,7-Dimethyl derivatives Edward M. Hawes, Dennis K. J. Gorecki, and Ronald G. Gedir pp 838 - 841; DOI: 10.1021/jm00216a021 |
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Cardenolide analogs. 2. 22-Methylenecard-14-enolides Dwight S. Fullerton, Thomas M. Gilman, Marvin C. Pankaskie, Khalil Ahmed, Arthur H. L. From, William L. Duax, and Douglas C. Rohrer pp 841 - 844; DOI: 10.1021/jm00216a022 |
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Diastereoisomeric N-tetrahydrofurfurylnoroxymorphones with opioid agonist-antagonist properties Herbert Merz, Klaus Stockhaus, and Helmut Wick pp 844 - 846; DOI: 10.1021/jm00216a023 |
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Synthesis and biological activity of some derivatives of thiochroman-4-one and tetrahydrothiapyran-4-one K. Ramalingam, George X. Thyvelikakath, K. Darrell Berlin, Robert W. Chesnut, Rebecca A. Brown, Norman N. Durham, Steven E. Ealick, and Dick Van der Helm pp 847 - 850; DOI: 10.1021/jm00216a024 |
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Preparation and antitumor activity of 1-aryl-3,3-dimethyltriazene derivatives T. Giraldi, C. Nisi, T. A. Connors, and P. M. Goddard pp 850 - 853; DOI: 10.1021/jm00216a025 |
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Antiinflammatory activity of 17-esters of 6.alpha.,9.alpha.-difluoro-21-deoxyprednisolone Romano Vitali, Serafino Gladiali, Giovanni Falconi, Giuseppe Celasco, and Rinaldo Gardi pp 853 - 854; DOI: 10.1021/jm00216a026 |
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Book Reviews pp 855 - 862; DOI: 10.1021/jm00216a600 |
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Thyroxine analogs. 23. Quantitative structure-activity correlation studies of in vivo and in vitro thyromimetic activities Stephen W. Dietrich, Michael B. Bolger, Peter A. Kollman, and Eugene C. Jorgensen pp 863 - 880; DOI: 10.1021/jm00217a001 |
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Absolute configuration of glycerol derivatives. 4. Synthesis and pharmacological activity of chiral 2-alkylaminomethylbenzodioxans, competitive .alpha.-adrenergic antagonists Wendel L. Nelson, John E. Wennerstrom, Donald C. Dyer, and Michael Engel pp 880 - 885; DOI: 10.1021/jm00217a002 |
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Various 5-substituted and 2,5-disubstituted 1,3-dioxanes, a new class of analgesic agents Richard N. Booher, Stephen E. Smits, William W. Turner, and Albert Pohland pp 885 - 890; DOI: 10.1021/jm00217a003 |
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Synthesis and biological evaluation of a tetrahydroisoquinoline derivative possessing selective .beta.2-adrenergic agonist activity Peter F. Kador, R. Venkatraman, Dennis R. Feller, and Duane D. Miller pp 891 - 894; DOI: 10.1021/jm00217a004 |
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Isoquinolines. 5. Synthesis and antiarrhythmic activity of benzylisoquinoline derivatives John L. Neumeyer, Cecily Perianayagam, Somsak Ruchirawat, Hal S. Feldman, Bertil H. Takman, and Paul A. Tenthorey pp 894 - 898; DOI: 10.1021/jm00217a005 |
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Synthesis of octanoyl[8-leucyl]angiotensin II, a lipophilic angiotensin antagonist Antonio C. M. Paiva, Viviane L. A. Nouailhetas, and Therezinha B. Paiva pp 898 - 901; DOI: 10.1021/jm00217a006 |
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Cyanoguanidine-thiourea equivalence in the development of the histamine H2-receptor antagonist, cimetidine G. J. Durant, J. C. Emmett, C. R. Ganellin, P. D. Miles, M. E. Parsons, H. D. Prain, and G. R. White pp 901 - 906; DOI: 10.1021/jm00217a007 |
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Synthesis, structure, and reactivity of adenosine cyclic 3',5'-phosphate-benzyltriesters Joachim Engels and Ernst Juergen Schlaeger pp 907 - 911; DOI: 10.1021/jm00217a008 |
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Antitumor agents. 25. Synthesis and antitumor activity of uracil and thymine .alpha.-methylene-.gamma.-lactones and related derivatives Kuo-Hsiung Lee, Yih-Shiong Wu, and Iris H. Hall pp 911 - 914; DOI: 10.1021/jm00217a009 |
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Microbial transformations of natural antitumor agents. 3. Conversion of thalicarpine to (+)-hernandalinol by Streptomyces punipalus T. Nabih, P. J. Davis, J. F. Caputo, and J. P. Rosazza pp 914 - 917; DOI: 10.1021/jm00217a010 |
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Dihydroretinoic acids and their derivatives. Synthesis and biological activity Beverly A. Pawson, H. C. Cheung, Ru-Jen L. Han, Patrick W. Trown, Margaret Buck, Roseanne Hansen, W. Bollag, U. Ineichen, H. Pleil, and et al. pp 918 - 925; DOI: 10.1021/jm00217a011 |
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Methotrexate analogs. 8. Synthesis and biological evaluation of bisamide derivatives as potential prodrugs Andre Rosowsky, William D. Ensminger, Herbert Lazarus, and Cheng-Sein Yu pp 925 - 930; DOI: 10.1021/jm00217a012 |
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Synthesis of cyclohexyl carbocyclic puromycin and its inhibition of protein synthesis Robert Vince and Susan Daluge pp 930 - 934; DOI: 10.1021/jm00217a013 |
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Isoxazole anthelmintics John B. Carr, Harry G. Durham, and D. Kendall Hass pp 934 - 939; DOI: 10.1021/jm00217a014 |
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Anticoccidial 1-substituted 4(1H)-pyridinone hydrazones A. W. Douglas, M. H. Fisher, J. J. Fishinger, P. Gund, E. E. Harris, G. Olson, A. A. Patchett, and W. V. Ruyle pp 939 - 943; DOI: 10.1021/jm00217a015 |
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Hydrophobicity of several rhodium(II) carboxylates correlated with their biologic activity R. A. Howard, E. Sherwood, A. Erck, A. P. Kimball, and J. L. Bear pp 943 - 946; DOI: 10.1021/jm00217a016 |
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Antiprotozoal thiazoles. 2. 2-(5-Nitro-2-furyl-, thiazolyl-, and 1-methylimidazolyl-)thiazoles Martin C. Neville and John P. Verge pp 946 - 949; DOI: 10.1021/jm00217a017 |
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Chemotherapy of murine ovarian carcinoma by methotrexate-antibody conjugates Sumner Burstein and Robert Knapp pp 950 - 952; DOI: 10.1021/jm00217a018 |
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Synthesis and central nervous system evaluation of some 5-alkoxy-3H-1,4-benzodiazepin-2(1H)-ones John H. Gogerty, Rudolf G. Griot, Dietmar Habeck, Louis C. Iorio, and William J. Houlihan pp 952 - 956; DOI: 10.1021/jm00217a019 |
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Synthesis of .epsilon.-rhodomycinone glycosides Hassan S. El Khadem, David L. Swartz, and Richard C. Cermak pp 957 - 960; DOI: 10.1021/jm00217a020 |
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Hydrolysis of 3-cloro-3-cephems. Intramolecular nucleophilic attack in cefaclor Joseph M. Indelicato, Alan Dinner, Lynn R. Peters, and William L. Wilham pp 961 - 963; DOI: 10.1021/jm00217a021 |
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Cephalosporin degradations Alan Dinner pp 963 - 965; DOI: 10.1021/jm00217a022 |
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3-Hydroxyisoxazole-5-hydroxamic acid John W. Hines and Charles H. Stammer pp 965 - 967; DOI: 10.1021/jm00217a023 |
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Peptide hormones. 95. Inhibition of the activity of the luteinizing hormone-releasing hormone (LH-RH) by analogs with variations at positions 2, 3, and 6 and the carboxyl terminus John Humphries, Yieh-Ping Wan, Karl Folkers, and Cyril Y. Bowers pp 967 - 969; DOI: 10.1021/jm00217a024 |
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.beta.-Adrenoceptor blocking activity of halogenated thienylethanolamine derivatives S. Conde, C. Corral, R. Madronero, A. Sanchez Alvarez-Insua, M. P. Fernandez-Tome, J. Del Rio, and M. Santos pp 970 - 974; DOI: 10.1021/jm00217a025 |
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Improved synthesis and in vitro antiviral activities of 5-cyanouridine and 5-cyano-2'-deoxyuridine Paul F. Torrence, Bharant Bhooshan, Johan Descamps, and Erik De Clercq pp 974 - 976; DOI: 10.1021/jm00217a026 |
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B/C-cis- and -trans-1,3,4,9,10,10a-hexahydro-2H-10,4a-methanoiminoethanophenanthrene (homo- and homoisomorphinan) derivatives as analgesics Shunsaku Shiotani and Tadashi Kometani pp 976 - 978; DOI: 10.1021/jm00217a027 |
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Agonist effects of .beta.-phenethylamines on the noradrenergic cyclic adenosine 3',5'-monophosphate generating system in rat limbic forebrain. Stereoisomers of p-hydroxynorephedrine Howard E. Smith, Elizabeth P. Burrows, Philip L. Mobley, Susan E. Robinson, and Fridolin Sulser pp 978 - 981; DOI: 10.1021/jm00217a028 |
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Differences in antischistosomal and mutagenic properties between an isothiocyano- and an isocyanonitrodiphenylamine A. W. Coulter, E. Bueding, and R. P. Batzinger pp 981 - 982; DOI: 10.1021/jm00217a029 |
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Book Reviews pp 982 - 986; DOI: 10.1021/jm00217a600 |
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Potential antitumor agents. 23. 4'-(9-Acridinylamino)alkanesulfonanilide congeners bearing hydrophilic functionality Bruce F. Cain, Graham J. Atwell, and William A. Denny pp 987 - 996; DOI: 10.1021/jm00218a001 |
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Biologically oriented organic sulfur chemistry. 15. Organic disulfides and related substances. 41. Inhibition of the fungal pathogen Histoplasma capsulatum by some organic disulfides Lamar Field, John A. R. Grimaldi, Wayne S. Hanley, Mark W. Holladay, Ramanathan Ravichandran, Lawrence J. Schaad, and C. Emory Tate pp 996 - 1001; DOI: 10.1021/jm00218a002 |
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Design, synthesis, and correlation analysis of 7-substituted 4-hydroxyquinoline-3-carboxylic acids as inhibitors of cellular respiration Kishorkant J. Shah and Eugene A. Coats pp 1001 - 1006; DOI: 10.1021/jm00218a003 |
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Hypolipidemic arylthioalkanoic acids Eugene R. Wagner, Robert G. Dull, Larry G. Mueller, Bobbie J. Allen, Alfred A. Renzi, Darrel J. Rytter, James W. Barnhart, and Carol Byers pp 1007 - 1013; DOI: 10.1021/jm00218a004 |
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Synthesis and stereospecific antipsychotic activity of (-)-1-cyclopropylmethyl-4-(3-trifluoromethylthio-5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine David C. Remy, Kenneth E. Rittle, Cecilia A. Hunt, Paul S. Anderson, Byron H. Arison, Edward L. Engelhardt, Ralph Hirschmann, Bradley V. Clineschmidt, Victor J. Lotti, and et al. pp 1013 - 1019; DOI: 10.1021/jm00218a005 |
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3-Hydroxy-17-aralkylmorphinans as potential opiate receptor-site-directed alkylating agents Philip S. Portoghese, Robert N. Hanson, Vasant G. Telang, Jan L. Winger, and A. E. Takemori pp 1020 - 1024; DOI: 10.1021/jm00218a006 |
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An approach to peripheral vasodilator-.beta.-adrenergic blocking agents J. J. Baldwin, R. Hirschmann, P. K. Lumma, W. C. Lumma, G. S. Ponticello, C. S. Sweet, and A. Scriabine pp 1024 - 1029; DOI: 10.1021/jm00218a007 |
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Adrenergic agents. 6. Synthesis and potential .beta.-adrenergic agonist activity of some meta-substituted p-hydroxyphenylethanolamines related to salbutamol Timothy Jen, James S. Frazee, Carl Kaiser, Donald F. Colella, and Joe R. Wardell pp 1029 - 1035; DOI: 10.1021/jm00218a008 |
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Central nervous system activity of a novel class of annelated 1,4-benzodiazepines, aminomethylene-2,4-dihydro-1H-imidazo[1,2-a][1,4]benzodiazepin-1-ones I. R. Ager, G. W. Danswan, D. R. Harrison, D. P. Kay, P. D. Kennewell, and J. B. Taylor pp 1035 - 1041; DOI: 10.1021/jm00218a009 |
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Prostaglandins and congeners. 14. Synthesis and bronchodilator activity of dl-16,16-trimethyleneprostaglandins Jerauld S. Skotnicki, Robert E. Schaub, Martin J. Weiss, and F. Dessy pp 1042 - 1047; DOI: 10.1021/jm00218a010 |
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Cholecystokinin (pancreozymin). 3. Synthesis and properties of an analog of the C-terminal heptapeptide with serine sulfate replacing tyrosine sulfate Miklos Bodanszky, Sesha Natarajan, William Hahne, and Jerry D. Gardner pp 1047 - 1050; DOI: 10.1021/jm00218a011 |
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Synthesis of angiotensin II antagonists by incorporating .alpha.-methylalanine or O-methylthreonine residues in angiotensin II analogs M. C. Khosla, H. Munoz-Ramirez, M. M. Hall, P. A. Khairallah, and F. M. Bumpus pp 1051 - 1055; DOI: 10.1021/jm00218a012 |
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2-Deaminoactinomycin D, synthesis and interaction with deoxyribonucleic acid Carol W. Mosher, Karl F. Kuhlmann, Dennis G. Kleid, and David W. Henry pp 1055 - 1059; DOI: 10.1021/jm00218a013 |
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Synthesis and antiallergic activity of 2-hydroxy-3-nitro-1,4-naphthoquinones Derek R. Buckle, Barrie C. C. Cantello, Harry Smith, Raymond J. Smith, and Barbara A. Spicer pp 1059 - 1064; DOI: 10.1021/jm00218a014 |
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Synthesis of two metabolites of (+)-propoxyphene William W. Turner, Richard N. Booher, Stephen E. Smits, and Albert Pohland pp 1065 - 1068; DOI: 10.1021/jm00218a015 |
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Experimental antiulcer drugs. 2. 2-substituted 2,4,5,6-tetrahydro-1,3,4,6,6-pentamethylcyclopenta[c]pyrrole-4-carboxamides Rudolf Oesterlin, Malcolm R. Bell, Ruthann H. McGarry, Allan G. Hlavac, James C. Bradford, and Janis Rozitis pp 1068 - 1071; DOI: 10.1021/jm00218a016 |
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Hydrogen-bonding parameter and its significance in quantitative structure-activity studies Toshio Fujita, Takaaki Nishioka, and Minoru Nakajima pp 1071 - 1081; DOI: 10.1021/jm00218a017 |
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Structure-activity relations in cephalosporins prepared from penicillins. 1. 7.beta.-Acylamino derivatives of 3-benzyl- and 3-(3-pyridylmethyl)ceph-3-em-4-carboxylic acids Edward G. Brain, A. John Eglington, John H. C. Nayler, Neal F. Osborne, Michael J. Pearson, Terence C. Smale, Robert Southgate, Patricia Tolliday, Michael J. Basker, and Robert Sutherland pp 1082 - 1085; DOI: 10.1021/jm00218a018 |
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Structure-activity relations in cephalosporins prepared from penicillins. 2. Analogs of cephalexin substituted in the 3-methyl group Edward G. Brain, A. John Eglington, Brian G. James, John H. C. Nayler, Neal F. Osborne, Michael J. Pearson, Terence C. Smale, Robert Southgate, Patricia Tolliday, and et al. pp 1086 - 1090; DOI: 10.1021/jm00218a019 |
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Structure and biological activity of (-)-[3H]-dihydroalprenolol, a radioligand for studies of .beta.-adrenergic receptors Malcolm H. Randall, Lawrence J. Altman, and Robert J. Lefkowitz pp 1090 - 1094; DOI: 10.1021/jm00218a020 |
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Pyrrole esters of tropanols and related structures as analgesics James A. Waters pp 1094 - 1096; DOI: 10.1021/jm00218a021 |
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Potential steroidal antiestrogens E. R. Clark, A. M. E. Omar, and G. Prestwich pp 1096 - 1099; DOI: 10.1021/jm00218a022 |
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Stereochemical studies on medicinal agents. 23. Synthesis and biological evaluation of 6-amino derivatives of naloxone and naltrexone Jack B. Jiang, Robert N. Hanson, Philip S. Portoghese, and A. E. Takemori pp 1100 - 1102; DOI: 10.1021/jm00218a023 |
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Isomers of erythro-5-(1-hydroxy-2-isopropylaminobutyl)-8-hydroxycarbostyril, a new bronchodilator Shiro Yoshizaki, Yoshiaki Manabe, Shigeharu Tamada, Kazuyuki Nakagawa, and Seiso Tei pp 1103 - 1104; DOI: 10.1021/jm00218a024 |
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Synthesis and biological activity of 8-arylergolines Nicholas J. Bach, Edmund C. Kornfeld, and Douglas E. Dorman pp 1105 - 1107; DOI: 10.1021/jm00218a025 |
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Modifications of primaquine as antimalarials. 1. 5-Phenoxy derivatives of primaquine Eugene H. Chen, Andrew J. Saggiomo, Keiichi Tanabe, Basant L. Verma, and Edward A. Nodiff pp 1107 - 1109; DOI: 10.1021/jm00218a026 |
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Book Reviews pp 1110 - 1110; DOI: 10.1021/jm00218a600 |
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Cerebral dopamine agonist properties of some 2-aminotetralin derivatives after peripheral and intracerebral administration Joseph G. Cannon, Teresa Lee, H. Duane Goldman, Brenda Costall, and Robert J. Naylor pp 1111 - 1116; DOI: 10.1021/jm00219a001 |
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Molecular structural effects involved in the interaction of quinolinemethanolamines with DNA. Implications for antimalarial action Michael W. Davidson, Billy G. Griggs, David W. Boykin, and W. David Wilson pp 1117 - 1122; DOI: 10.1021/jm00219a002 |
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Antimalarials. 10. Synthesis of 4-substituted primaquine analogs as candidate antimalarials Maurice P. LaMontagne, Anica Markovac, and John R. Menke pp 1122 - 1127; DOI: 10.1021/jm00219a003 |
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Potential antitumor agents. 24. Dicationic analogs of the 4'-(9-acridinylamino)alkanesulfonanilides Graham J. Atwell, Bruce F. Cain, and William A. Denny pp 1128 - 1134; DOI: 10.1021/jm00219a004 |
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Synthesis and biological action of two glucocorticoid alkylating agents Ahmed H. El Masry, Virginia C. Braun, Carl J. Nielsen, and William B. Pratt pp 1134 - 1139; DOI: 10.1021/jm00219a005 |
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Quantitative relations between steroid structure and binding to putative progesterone receptors David L. Lee, Peter A. Kollman, Fred J. Marsh, and Manfred E. Wolff pp 1139 - 1146; DOI: 10.1021/jm00219a006 |
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A model for the prostaglandin synthetase cyclooxygenation site and its inhibition by antiinflammatory arylacetic acids Peter Gund and T. Y. Shen pp 1146 - 1152; DOI: 10.1021/jm00219a007 |
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Synthesis and gastric antisecretory properties of 15-deoxy-16-hydroxyprostaglandin E analogs Paul W. Collins, Esam Z. Dajani, Doyle R. Driskill, Mildred S. Bruhn, Christopher J. Jung, and Raphael Pappo pp 1152 - 1159; DOI: 10.1021/jm00219a008 |
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Orally active esters of cephalosporin antibiotics. Synthesis and biological properties of acyloxymethyl esters of 7-(D-2-amino-2-phenylacetamido)-3-[5-methyl-(1,3,4-thiadiazol-2-yl)thiomethyl]-3-cephem-4-carboxylic acid W. J. Wheeler, W. E. Wright, V. D. Line, and J. A. Frogge pp 1159 - 1164; DOI: 10.1021/jm00219a009 |
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Synthesis and biological activity of some broad-spectrum N-acylphenylglycine cephalosporins R. M. DeMarinis, J. C. Boehm, J. V. Uri, J. R. Guarini, L. Phillips, and G. L. Dunn pp 1164 - 1169; DOI: 10.1021/jm00219a010 |
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Synthesis and some pharmacological properties of [4-homoserine]oxytocin Andras Turan, Maurice Manning, Jaya Haldar, and Wilbur H. Sawyer pp 1169 - 1172; DOI: 10.1021/jm00219a011 |
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[1-(L-2-Hydroxy-3-mercaptopropanoic acid)] analogs of arginine-vasopressin, [8-D-arginine]vasopressin, and [4-valine,8-D-arginine]vasopressin John Lowbridge, Maurice Manning, Jaya Haldar, and Wilbur Sawyer pp 1173 - 1176; DOI: 10.1021/jm00219a012 |
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Potential inhibitors of collagen biosynthesis. 4,4-Difluoro-L-proline and 4,4-dimethyl-DL-proline and their activation by prolyl-tRNA ligase Frances N. Shirota, Herbert T. Nagasawa, and James A. Elberling pp 1176 - 1181; DOI: 10.1021/jm00219a013 |
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Inhibitors of Bacillus subtilis DNA polymerase III. Structure-activity relations of 6-(phenylhydrazino)uracils George E. Wright and Neal C. Brown pp 1181 - 1185; DOI: 10.1021/jm00219a014 |
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Inhibitors of Bacillus subtilis DNA polymerase III. 6-(Arylalkylamino)uracils and 6-anilinouracils Neal C. Brown, Joseph Gambino, and George E. Wright pp 1186 - 1189; DOI: 10.1021/jm00219a015 |
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2-Pyridylimidazoles as inhibitors of xanthine oxidase J. J. Baldwin, P. K. Lumma, F. C. Novello, G. S. Ponticello, J. M. Sprague, and D. E. Duggan pp 1189 - 1193; DOI: 10.1021/jm00219a016 |
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Inhibitors of hepatic mixed function oxidase. 3. Inhibition of hepatic microsomal aniline hydroxylase and aminopyrine demethylase by 2,6- and 2,4-dihydroxyphenyl alkyl ketones and related compounds Alex Bobik, Gerald M. Holder, and Adrian J. Ryan pp 1194 - 1199; DOI: 10.1021/jm00219a017 |
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Oxime ether derivatives, a new class of nonsteroidal antiinflammatory compounds Jan Van Dijk and Jan M. A. Zwagemakers pp 1199 - 1206; DOI: 10.1021/jm00219a018 |
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Electronic factors in the structure-activity relations of some 1,4-benzodiazepin-2-ones T. Blair and G. A. Webb pp 1206 - 1210; DOI: 10.1021/jm00219a019 |
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Potential long-acting anticonvulsants. 2. Synthesis and activity of succinimides containing an alkylating group on nitrogen or at the 3 position Milton J. Kornet, A. Michael Crider, and Edward O. Magarian pp 1210 - 1213; DOI: 10.1021/jm00219a020 |
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Inhibitors of folate biosynthesis. 1. Inhibition of dihydroneopterin aldolase by pteridine derivatives Morris Zimmerman, Richard L. Tolman, Harriet Morman, Donald W. Graham, and Edward F. Rogers pp 1213 - 1215; DOI: 10.1021/jm00219a021 |
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Pteridines. 41. Synthesis and dihydrofolate reductase inhibitory activity of some cycloalka[g]pteridines Edward C. Taylor, John V. Berrier, Anthony J. Cocuzza, Ryszard Kobylecki, and John J. McCormack pp 1215 - 1218; DOI: 10.1021/jm00219a022 |
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Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)thiophenes and -pyrroles Bijan P. Das and David W. Boykin pp 1219 - 1221; DOI: 10.1021/jm00219a023 |
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Effect of the solvent-dependent conformational system of hydroxyureas on predicted vs. observed log P George R. Parker, Thomas L. Lemke, and E. Colleen Moore pp 1221 - 1225; DOI: 10.1021/jm00219a024 |
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4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide Helmut Mrozik, Richard J. Bochis, Philip Eskola, Alexander Matzuk, Frank S. Waksmunski, Leonard E. Olen, George Schwartzkopf Jr., Alex Grodski, Bruce O. Linn, and et al. pp 1225 - 1227; DOI: 10.1021/jm00219a025 |
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[1-Deaminopenicillamine,4-valine]-8-D-arginine-vasopressin, a highly potent inhibitor of the vasopressor response to arginine-vasopressin Maurice Manning, John Lowbridge, Charles T. Stier, Jaya Haldar, and W. H. Sawyer pp 1228 - 1230; DOI: 10.1021/jm00219a026 |
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Book Reviews pp 1230 - 1234; DOI: 10.1021/jm00219a600 |
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Monomethylthio analogs of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane Peyton Jacob, George Anderson, Charles K. Meshul, Alexander T. Shulgin, and Neal Castagnoli pp 1235 - 1239; DOI: 10.1021/jm00220a001 |
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Glyoxalase I enzyme studies. 3. Synthesis and evaluation of .alpha.-hydroxythiol esters as antitumor agents and glyoxalase I inhibitors Stan S. Hall, Lidia M. Doweyko, Arthur M. Doweyko, and Judith S. Ryan Zilenovski pp 1239 - 1242; DOI: 10.1021/jm00220a002 |
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Potential antitumor agents. 25. Azalogs of the 4'-(9-acridinylamino)methanesulfonanilides William A. Denny, Graham J. Atwell, and Bruce F. Cain pp 1242 - 1246; DOI: 10.1021/jm00220a003 |
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Synthesis of nitrosourea derivatives of sucrose as central nervous system anticancer agents Ronald G. Almquist and Elmer J. Reist pp 1246 - 1250; DOI: 10.1021/jm00220a004 |
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Synthesis and preliminary pharmacological activity of aminoalkoxy isosteres of glycolate ester anticholinergics David S. Fries, John Andrako, and Patricia Hudgins pp 1250 - 1254; DOI: 10.1021/jm00220a005 |
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.beta.-Adrenergic blocking agents. 16. 1-(Acylaminomethyl-, ureidomethyl-, and ureidoethylphenoxy)-3-amino-2-propanols L. H. Smith pp 1254 - 1258; DOI: 10.1021/jm00220a006 |
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Adrenergic agents. 8. Synthesis and .beta.-adrenergic agonist activity of some 3-tert-butylamino-2-(substituted phenyl)-1-propanols Timothy Jen, James S. Frazee, Mark S. Schwartz, Karl F. Erhard, Carl Kaiser, Donald F. Colella, and Joe R. Wardell pp 1263 - 1268; DOI: 10.1021/jm00220a007 |
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2-(2-Aminoethylamino)-1,2-diphenylethanol derivatives, a new class of topical antiinflammatory agents R. Ian Fryer, Alfred Boris, James V. Earley, and Earl Reeder pp 1268 - 1272; DOI: 10.1021/jm00220a008 |
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3-N-Substituted aminomethyl derivatives of rifamycin SV. A convenient method of synthesis, cyclization of certain derivatives, and anticellular and antiviral activities of several derivatives James R. McCarthy, Jim L. Moore, Don V. Wysong, and Charles D. Aldrich pp 1272 - 1276; DOI: 10.1021/jm00220a009 |
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Effect of colloidal association on the measured activity of alkylbenzyldimethylammonium chlorides against Pseudomonas aeruginosa E. Tomlinson, M. R. W. Brown, and S. S. Davis pp 1277 - 1282; DOI: 10.1021/jm00220a010 |
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Polynucleotide analogs. Copolymers of vinyl bases with acrylic acid, methylacrylic acid, acrylamide, and 1-vinylpyrrolidone Linda Maggiora, Sophie Boguslawski, and Mathias P. Mertes pp 1283 - 1287; DOI: 10.1021/jm00220a011 |
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Synthesis and antibacterial activity of some derivatives of tolypomycinone. Relation between structure and activity in ansamycins Piero Bellomo, Mario Brufani, Egidio Marchi, Giuseppe Mascellani, William Melloni, Lauretta Montecchi, and Luciano Stanzani pp 1287 - 1291; DOI: 10.1021/jm00220a012 |
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Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives Robert L. Smith, Ta-Jyh Lee, Norman P. Gould, Edward J. Cragoe, Helen G. Oien, and Frederick A. Kuehl pp 1292 - 1299; DOI: 10.1021/jm00220a013 |
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11,12-Secoprostaglandins. 4. 7-(N-Alkylmethanesulfonamido)heptanoic acids James H. Jones, Wilbur J. Holtz, John B. Bicking, Edward J. Cragoe, Lewis R. Mandel, and Frederick A. Kuehl pp 1299 - 1304; DOI: 10.1021/jm00220a014 |
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Synthesis and antimineralocorticoid activities of some 6-substituted 7.alpha.-carboalkoxy steroidal spirolactones Richard M. Weier and Lorenz M. Hofmann pp 1304 - 1308; DOI: 10.1021/jm00220a015 |
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Synthesis of spin-labeled nitroxyl esters of steroids Walter R. Benson, Millard Maienthal, George C. Yang, Eric B. Sheinin, and C. W. Chung pp 1308 - 1312; DOI: 10.1021/jm00220a016 |
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Quinazolines and 1,4-benzodiazepines. 82. 5-Pyrimidyl- and 5-pyrazinylbenzodiazepines Giles A. Archer, Robert I. Kalish, Robert Y. Ning, Barbara C. Sluboski, Arthur Stempel, Thomas V. Steppe, and Leo H. Sternbach pp 1312 - 1317; DOI: 10.1021/jm00220a017 |
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Compounds with gastric antisecretory activity. 1. Phenoxyalkylamines Peter E. Cross, Roger P. Dickinson, John E. G. Kemp, Peter R. Leeming, and Laurence G. Pullman pp 1317 - 1323; DOI: 10.1021/jm00220a018 |
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Methotrexate analogs. 9. Synthesis and biological properties of some 8-alkyl-7,8-dihydro analogs Michael Chaykovsky, Margaret Hirst, Herbert Lazarus, Jack E. Martinelli, Roy L. Kisliuk, and Yvette Gaumont pp 1323 - 1327; DOI: 10.1021/jm00220a019 |
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Antifilarial agents. 1,2-Cyclobutanediamines as analogs of diethylcarbamazine. Status of structure-activity relations among diethylcarbamazine analogs Priscilla A. Sturm, Michael Cory, David W. Henry, J. W. McCall, and J. B. Ziegler pp 1327 - 1333; DOI: 10.1021/jm00220a020 |
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Antifilarial agents. 3-Aminopyrrolidine and 1,4-diazabicyclo[3.2.1]octane derivatives as analogs of diethylcarbamazine Priscilla A. Sturm, Michael Cory, David W. Henry, J. W. McCall, and J. B. Ziegler pp 1333 - 1337; DOI: 10.1021/jm00220a021 |
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Quinoline derivatives as antiallergy agents. 2. Fused-ring quinaldic acids Charles M. Hall, John B. Wright, Herbert G. Johnson, and Arlen J. Taylor pp 1337 - 1343; DOI: 10.1021/jm00220a022 |
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Nonsteroidal antiinflammatory agents. 2. Synthesis and biological activity of 2-chloroindolecarboxylic acids Aldo Andreani, Daniela Bonazzi, Mirella Rambaldi, Adriano Guarnieri, Franco Andreani, Paola Strocchi, and Nicola Montanaro pp 1344 - 1346; DOI: 10.1021/jm00220a023 |
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Lysergic acid diethylamide. Photoelectron ionization potentials as indices of behavioral activity L. N. Domelsmith, Linda L. Munchausen, and K. N. Houk pp 1346 - 1348; DOI: 10.1021/jm00220a024 |
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Synthesis of 2-benzyloxy and 2-benzylthio analogs of primaquine as potential antimalarials Raghav V. Shetty, William P. Wetter, and C. DeWitt Blanton pp 1349 - 1351; DOI: 10.1021/jm00220a025 |
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Synthesis of 5,6-dihydro-8(7H)-quinolinone thiosemicarbazones as potential antitumor agents Thomas L. Lemke, Tak Wai Shek, L. A. Cates, Lewis K. Smith, Lucille A. Cosby, and Alan C. Sartorelli pp 1351 - 1354; DOI: 10.1021/jm00220a026 |
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Synthesis and determination of antiviral activity of the 2'(3')-O-methyl derivatives of ribavirin (1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) L. Dudycz, D. Shugar, E. De Clercq, and J. Descamps pp 1354 - 1356; DOI: 10.1021/jm00220a027 |
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Adrenergic Agents. 7. Synthesis and β-Adrenergic Agonist Activity of Several 2-Pyridylethanolamines Timothy Jen, James S. Frazee, Mark S. Schwartz, and Carl Kaiser pp 1258 - 1262; DOI: 10.1021/jm00220a600 |
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Chemoimmunotherapy of cancer. 2 A. H. Soloway, J. E. Wright, V. Subramanyam, and J. J. Gozzo pp 1357 - 1362; DOI: 10.1021/jm00221a001 |
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Antitumor septacidin analogs Edward M. Acton, Kenneth J. Ryan, and Arthur E. Luetzow pp 1362 - 1371; DOI: 10.1021/jm00221a002 |
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Biologically active polycycloalkanes. 4. Phosphoric esters of trimethylenenorbornyl alcohols Yoshiaki Inamoto, Koji Aigami, Takeji Kadono, Hirokazu Nakayama, Akira Takatsuki, and Gakuzo Tamura pp 1371 - 1374; DOI: 10.1021/jm00221a003 |
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Synthesis and pharmacological activity of some N-alkyl-substituted 9.alpha.-ethyl-2'-hydroxy-5-methyl-6,7-benzomorphans Ibrahim M. Uwaydah, Everette L. May, and Louis S. Harris pp 1374 - 1377; DOI: 10.1021/jm00221a004 |
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Synthesis and hypotensive activity of some cyclopentano-1,2,3,4-tetrahydroisoquinolines Ian W. Mathison, William E. Solomons, Norbert J. Wojciechowski, and James W. Lawson pp 1378 - 1384; DOI: 10.1021/jm00221a005 |
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A new type of anticonvulsant: 1-aryl-3-oxotetrahydroisoquinolines G. Deak, M. Doda, L. Gyorgy, L. Hazai, and L. Sterk pp 1384 - 1388; DOI: 10.1021/jm00221a006 |
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Hypolipidemic analogs of ethyl 4-benzyloxybenzoate Keith H. Baggaley, Robin Fears, Richard M. Hindley, Brian Morgan, Elspeth Murrell, and David E. Thorne pp 1388 - 1393; DOI: 10.1021/jm00221a007 |
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Synthesis of quinazoline analogs of folic acid modified at position 10 John E. Oatis and John B. Hynes pp 1393 - 1396; DOI: 10.1021/jm00221a008 |
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Synthesis of prostaglandin synthetase substrate analogs. 2. (8Z,11Z,14Z)-15-Methyl-8,11,14-eicosatrienoic acid Marcia I. Dawson, Margaret Reid, Martin E. Hemler, and William E. M. Lands pp 1396 - 1400; DOI: 10.1021/jm00221a009 |
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(Acylaryloxy)acetic acid diuretics. 1. (2-Alkyl- and 2,2-dialkyl-1-oxo-5-indanyloxy)acetic acids Otto W. Woltersdorf, S. Jane DeSolms, Everett M. Schultz, and Edward J. Cragoe pp 1400 - 1408; DOI: 10.1021/jm00221a010 |
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Neurotensin analogs. Structure-activity relationships Jean E. Rivier, Lawrence H. Lazarus, Marilyn H. Perrin, and Marvin R. Brown pp 1409 - 1412; DOI: 10.1021/jm00221a011 |
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Application of the Free-Wilson technique to structurally related series of homologs. Quantitative structure-activity relationship studies of narcotic analgetics Robert Katz, Steven F. Osborne, and Florin Ionescu pp 1413 - 1419; DOI: 10.1021/jm00221a012 |
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Quantitative structure-activity relationship of chymotrypsin-ligand interactions Corwin Hansch, Ciro Grieco, Carlo Silipo, and Antonio Vittoria pp 1420 - 1435; DOI: 10.1021/jm00221a013 |
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Improved delivery through biological membranes. 4. Prodrugs of L-DOPA Nicholas Bodor, Kenneth B. Sloan, Takeru Higuchi, and Kunihiro Sasahara pp 1435 - 1445; DOI: 10.1021/jm00221a014 |
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Antibacterial halogenoacetyl derivatives of amino acids and simple peptides Jennifer Goodacre, Leonard Jeffries, John H. C. Nayler, Roger J. Ponsford, and Irene Stirling pp 1445 - 1448; DOI: 10.1021/jm00221a015 |
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Synthesis of .beta.-spiro[pyrrolidinoindolines], their binding to the glycine receptor, and in vivo biological activity Fred M. Hershenson, Kathleen A. Prodan, Ronald L. Kochman, James L. Bloss, and Carl R. Mackerer pp 1448 - 1451; DOI: 10.1021/jm00221a016 |
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Synthesis of a fragment of human parathyroid hormone, hPTH-(44-68) Michael Rosenblatt, Henry T. Keutmann, Geoffrey W. Tregear, and John T. Potts pp 1452 - 1456; DOI: 10.1021/jm00221a017 |
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Conformation-activity studies of oxytocin. Effects of structural modifications at corner positions of the .beta.-turns on the uterotonic activity Clark W. Smith, Christopher R. Botos, Gerald Skala, and Roderich Walter pp 1457 - 1460; DOI: 10.1021/jm00221a018 |
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Synthesis and pharmacological properties of the N-terminal decapeptide of the vasoactive intestinal peptide (VIP) Miklos Bodanszky, Jill B. Henes, Athanasios E. Yiotakis, and Sami I. Said pp 1461 - 1464; DOI: 10.1021/jm00221a019 |
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Proteinase inhibitors. 1. Inhibitors of elastase Conrad P. Dorn, Morris Zimmerman, Shu Shu Yang, Edward C. Yurewicz, Bonnie M. Ashe, Robert Frankshun, and Howard Jones pp 1464 - 1468; DOI: 10.1021/jm00221a020 |
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Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship Yusuke Wataya, Daniel V. Santi, and Corwin Hansch pp 1469 - 1473; DOI: 10.1021/jm00221a021 |
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Ergot alkaloids. Synthesis of 6-alkyl-8-ergolenes and 6-methyl-8-aminoergolines as potential prolactin inhibitors A. Michael Crider, J. Michael Robinson, Heinz G. Floss, John M. Cassady, and James A. Clemens pp 1473 - 1477; DOI: 10.1021/jm00221a022 |
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Selective inhibition of the monosynaptic spinal reflex by a series of hydroxylated alkylaminoindans Joseph E. Sundeen, Joyce A. Reid, Judith A. Osband, and Frederick P. Hauck pp 1478 - 1485; DOI: 10.1021/jm00221a023 |
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Synthesis of 3-(4-acylaminopiperazin-1-ylalkyl)indoles as potential antihypertensive agents Edward J. Glamkowski, Philip A. Reitano, and David L. Woodward pp 1485 - 1489; DOI: 10.1021/jm00221a024 |
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Structure of warfarin in solution E. J. Valente, E. C. Lingafelter, W. R. Porter, and W. F. Trager pp 1489 - 1493; DOI: 10.1021/jm00221a025 |
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Azabicyclo chemistry. 6. An investigation of one of the chemical parameters for analgetic activity. Synthesis of 2-methyl-2-azabicyclo[3.3.1]non-6-ene and -non-7-ene Richard C. Cavestri and Michael Mokotoff pp 1493 - 1496; DOI: 10.1021/jm00221a026 |
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Heterocyclic and piperonylic acid esters of 1-methyl-4-piperidinol as analgesics James A. Waters pp 1496 - 1499; DOI: 10.1021/jm00221a027 |
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Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 3. .omega.-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)alkanoic acids Daniel E. Aultz, Arthur R. McFadden, and Howard B. Lassman pp 1499 - 1501; DOI: 10.1021/jm00221a028 |
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Synthesis of 1-substituted analogs of trimetoquinol possessing differential and selective .beta.-adrenergic properties Duane D. Miller, Peter Osei-Gyimah, Rajeswari V. Raman, and Dennis R. Feller pp 1502 - 1504; DOI: 10.1021/jm00221a029 |
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Isoquinolines. 6. Potential central nervous system antitumor agents. Nitrogen mustards of 3-amino-4-(p-aminophenyl)isoquinoline Crist N. Filer, Felix E. Granchelli, Albert H. Soloway, and John L. Neumeyer pp 1504 - 1508; DOI: 10.1021/jm00221a030 |
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Cannabinoids. Synthesis and central nervous system activity of 8-substituted 10-hydroxy-5,5-dimethyl-5H-[1]benzopyrano[4,3-c]pyridine and derivatives Cheuk-Man Lee, Raymond J. Michaels, Harold E. Zaugg, Anthony T. Dren, Nicolas P. Plotnikoff, and Patrick R. Young pp 1508 - 1511; DOI: 10.1021/jm00221a031 |
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Antimycotic imidazoles. 2. Synthesis and antimycotic properties of 1-[2-(arylalkyl)-2-phenylethyl]-1H-imidazoles Jan Heeres, Jozef H. Mostmans, and Jan Van Cutsem pp 1511 - 1516; DOI: 10.1021/jm00221a032 |
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Antimycotic imidazoles. 3. Synthesis and antimycotic properties of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles Jan Heeres, Leo J. J. Backx, and Jan Van Cutsem pp 1516 - 1520; DOI: 10.1021/jm00221a033 |
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4-Substituted semicarbazones of mono- and dichlorobenzaldehydes as antihypertensive agents James D. Warren, David L. Woodward, and Ronald T. Hargreaves pp 1520 - 1521; DOI: 10.1021/jm00221a034 |
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Synthesis and biological activity of two metabolites of 1-methyl-5-(1-methylethyl)-2-nitro-1H-imidazole, an antiprotozoal agent Bruno Cavalleri, Giancarlo Volpe, Vittorio Arioli, and Giancarlo Lancini pp 1522 - 1525; DOI: 10.1021/jm00221a035 |
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Prostaglandin prodrugs. 5. Prostaglandin E2 ethylene ketal Moo J. Cho, Gordon L. Bundy, and John J. Biermacher pp 1525 - 1527; DOI: 10.1021/jm00221a036 |
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Synthesis and antitumor properties of bis(quinaldine) derivatives Birandra K. Sinha, R. M. Philen, R. Sato, and R. L. Cysyk pp 1528 - 1531; DOI: 10.1021/jm00221a037 |
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Diastereoisomers of 5,10-methylene-5,6,7,8-tetrahydropteroyl-D-glutamic acid R. L. Kisliuk, D. Strumpf, Y. Gaumont, R. P. Leary, and L. Plante pp 1531 - 1533; DOI: 10.1021/jm00221a038 |
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Book Reviews pp 1533 - 1542; DOI: 10.1021/jm00221a600 |
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Synthesis and body distribution of several iodine-131-labeled central nervous system active drugs Ulrich Braun, Alexander T. Shulgin, Gisela Braun, and Thornton Sargent pp 1543 - 1546; DOI: 10.1021/jm00222a001 |
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Contragestational agents. 1. Steroidal-O-aryloximes Allen F. Hirsch, George O. Allen, Benny Wong, Sandra Reynolds, Chris Exarhos, William Brown, and Do Won Hahn pp 1546 - 1551; DOI: 10.1021/jm00222a002 |
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Prostaglandins and congeners. 15. Synthesis and bronchodilator activity of dl-11-deoxy-15- or 16-alkylprostaglandins Jerauld S. Skotnicki, Robert E. Schaub, Karel F. Bernady, Gerald J. Siuta, John F. Poletto, Martin J. Weiss, and Franz Dessy pp 1551 - 1557; DOI: 10.1021/jm00222a003 |
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Dibenztroponeacetic and- propionic acids. Potent new antiinflammatory agents James P. Dunn, Dallas M. Green, Peter H. Nelson, Wendell H. Rooks, Albert Tomolonis, and Karl G. Untch pp 1557 - 1562; DOI: 10.1021/jm00222a004 |
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Pyrazolodiazepines. 2. 4-Aryl-1,3-dialkyl-6,8-dihydropyrazolo[3,4-e][1,4]diazepin-7(1H)-ones as antianxiety and anticonvulsant agents Horace A. DeWald, Sandra Lobbestael, and Donald E. Butler pp 1562 - 1569; DOI: 10.1021/jm00222a005 |
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Antischistosomal effects of 5-(2,4,5-trichlorophenyl)hydantoin and related compounds Leslie M. Werbel, Edward F. Elslager, Peter J. Islip, and M. D. Closier pp 1569 - 1572; DOI: 10.1021/jm00222a006 |
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Synthesis and hypoglycemic activity of 4-substituted 3-mercaptopicolinic acids Benjamin Blank, Nicholas W. DiTullio, Linda Deviny, John T. Roberts, Arthur Magnani, Marlyn Billig, and Harry L. Saunders pp 1572 - 1577; DOI: 10.1021/jm00222a007 |
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Antineoplastic agents. 1. N-Protected vinyl, 1,2-dihaloethyl, and cyanomethyl esters of phenylalanine Larry J. Loeffler, Ziaodin Sajadi, and Iris H. Hall pp 1578 - 1584; DOI: 10.1021/jm00222a008 |
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Antineoplastic agents. 2. Structure-activity studies on N-protected vinyl, 1,2-dibromoethyl, and cyanomethyl esters of several amino acids Larry J. Loeffler, Ziaodin Sajadi, and Iris H. Hall pp 1584 - 1588; DOI: 10.1021/jm00222a009 |
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Nitramino acids. Synthesis and biological evaluation of 1-nitroproline, 1-nitropipecolic acid, and N-nitrosarcosine Herbert T. Nagasawa, William P. Muldoon, and Frances N. Shirota pp 1588 - 1591; DOI: 10.1021/jm00222a010 |
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Studies of antitumor agents. 1. Resolution of racemic 1-(tetrahydro-2-furanyl)-5-fluorouracil into the R and S isomers and examination of the biological activities of the isomers Mitsugi Yasumoto, Akira Moriyama, Norio Unemi, Sadao Hashimoto, and Takashi Suzue pp 1592 - 1594; DOI: 10.1021/jm00222a011 |
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Carbon-13 nuclear magnetic resonance investigations into the interactions of bisulfite with pyrimidine nucleosides and nucleotides J. W. Triplett, S. L. Smith, W. J. Layton, and G. A. Digenis pp 1594 - 1597; DOI: 10.1021/jm00222a012 |
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Synthesis and biological activities of some N6- and N9-carbamoyladenines and related ribonucleosides S. P. Dutta, C. I. Hong, G. L. Tritsch, C. Cox, R. Parthasarthy, and G. B. Chheda pp 1598 - 1607; DOI: 10.1021/jm00222a013 |
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Synthetic models of deoxyribonucleic acid complexes with antimalarial compounds. 3. Forces involved in the stacking interaction between aminoquinoline and the nucleotide bases J. Bolte, C. Demuynck, and J. Lhomme pp 1607 - 1611; DOI: 10.1021/jm00222a014 |
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Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates Edward R. Atkinson, Donna D. McRitchie, Linda F. Shoer, Louis S. Harris, Sydney Archer, Mario D. Aceto, J. Pearl, and F. P. Luduena pp 1612 - 1617; DOI: 10.1021/jm00222a015 |
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Potent reversible anticholinesterase agents. Bis- and mono-N-substituted benzoquinolinium halides Wen-Sherng Chen, George H. Cocolas, Chester J. Cavallito, and Kyung Ja Chai pp 1617 - 1623; DOI: 10.1021/jm00222a016 |
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Potential inhibitors of collagen biosynthesis. 5,5-Difluoro-DL-lysine and 5,5-dimethyl-DL-lysine and their activation by lysyl-tRNA ligase Frances N. Shirota, Herbert T. Nagasawa, and James A. Elberling pp 1623 - 1627; DOI: 10.1021/jm00222a017 |
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Molecular structure of thyroxine analogs. Crystal structure of 3,5,3'-triiodothyroacetic and 3,5,3'.5'-tetraiodothyroacetic acid N-diethanolamine (1:1) complexes Vivian Cody, John Hazel, David A. Langs, and William L. Duax pp 1628 - 1631; DOI: 10.1021/jm00222a018 |
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Structure-activity studies on hallucinogenic amphetamines using molecular connectivity Lemont B. Kier and Lowell H. Hall pp 1631 - 1636; DOI: 10.1021/jm00222a019 |
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Quantitative structure-activity relationships in centrally acting imidazolidines structurally related to clonidine Pieter B. M. W. M. Timmermans and Pieter A. Van Zwieten pp 1636 - 1644; DOI: 10.1021/jm00222a020 |
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Molecular orbital studies on the mechanism of drug-receptor interaction. 2. .beta.-Adrenergic drugs. An approach to explain the role of the aromatic moiety Carlo Petrongolo, Bruno Macchia, Franco Macchia, and Adriano Martinelli pp 1645 - 1653; DOI: 10.1021/jm00222a021 |
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.beta.-Adrenergic blocking agents. 17. 1-Phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propanols L. H. Smith and H. Tucker pp 1653 - 1656; DOI: 10.1021/jm00222a022 |
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Synthesis and .beta.-adrenergic blocking activity of a novel class of aromatic oxime ethers Gerard Leclerc, Andre Mann, Camille Georges Wermuth, Nicole Bieth, and Jean Schwartz pp 1657 - 1662; DOI: 10.1021/jm00222a023 |
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Prostaglandins and congeners. 16. Synthesis and bronchodilator activity of dl-11-deoxy-3-thiaprostaglandins Jerauld S. Skotnicki, Robert E. Schaub, Martin J. Weiss, and Franz Dessy pp 1662 - 1665; DOI: 10.1021/jm00222a024 |
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3-(3-Substituted prop-1-enyl)cephalosporins Philip J. Beeby and J. A. Edwards pp 1665 - 1668; DOI: 10.1021/jm00222a025 |
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Analogs of sparteine. 5. Antiarrhythmic activity of selected N,N'-disubstituted bispidines Peter C. Ruenitz and Corwin M. Mokler pp 1668 - 1671; DOI: 10.1021/jm00222a026 |
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Potential histidine decarboxylase inhibitors. 1. .alpha.- and .beta.-Substituted histidine analogs J. I. DeGraw, J. Engstrom, M. Ellis, and H. L. Johnson pp 1671 - 1674; DOI: 10.1021/jm00222a027 |
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Nonapeptide ethylamide inhibitors of the luteinizing hormone-releasing hormone (LH-RH) having a D-alanyl residue in position 6 and variations at positions 2 and 3 John Humphries, Yieh-Ping Wan, Karl Folkers, and Cyril Y. Bowers pp 1674 - 1677; DOI: 10.1021/jm00222a028 |
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Potential carcinostatics. Synthesis and biological properties of d- and l-.beta.,.beta.-difluoroaspartic acid and .beta.,.beta.-difluoroasparagine Johanna J. M. Hageman, Martinus J. Wanner, Gerrit Jan Koomen, and Upendra K. Pandit pp 1677 - 1679; DOI: 10.1021/jm00222a029 |
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Bradykinin potentiating and sensitizing activities of new synthetic analogs of snake venom peptides Elisabeth B. Sabia, Mineko Tominaga, Antonio C. M. Paiva, and Therezinha B. Paiva pp 1679 - 1681; DOI: 10.1021/jm00222a030 |
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(+)- and (-)-3-Methoxycyproheptadine. A comparative evaluation of the antiserotonin, antihistaminic, anticholinergic, and orexigenic properties with cyproheptadine David C. Remy, Kenneth E. Rittle, Cecilia A. Hunt, Paul S. Anderson, Edward L. Engelhardt, Bradley V. Clineschmidt, and Alexander Scriabine pp 1681 - 1684; DOI: 10.1021/jm00222a031 |
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1,2,4-Triazole amino nucleosides. 1-.beta.-D-3'-amino-3'-deoxyribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides A. S. Narang and Robert Vince pp 1684 - 1687; DOI: 10.1021/jm00222a032 |
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Aminobenzoic acid diuretics. 9. 3,4-Disubstituted 5-acylaminobenzoic acids and related compounds Peter W. Feit and Ole B. Tvaermose Nielsen pp 1687 - 1691; DOI: 10.1021/jm00222a033 |
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Vinylogous carbinolamine tumor inhibitors. 3. Antileukemic activity of derivatives of 1-phenyl-2,5-dimethyl-3,4-bis(hydroxymethyl)pyrrole bis(N-methylcarbamate) Wayne K. Anderson and Paul F. Corey pp 1691 - 1694; DOI: 10.1021/jm00222a034 |
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Quinazolines and 1,4-benzodiazepines. 81. s-Triazolo[4,3-a][1,4]benzodiazepines by oxidative cyclization of hydrazones Armin Walser and Gladys Zenchoff pp 1694 - 1697; DOI: 10.1021/jm00222a035 |
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Nitroimidazoles with antibacterial activity against Neisseria gonorrhoeae Robert C. Tweit, R. D. Muir, and Sylvia Ziecina pp 1697 - 1700; DOI: 10.1021/jm00222a036 |
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Chemoimmunotherapy of cancer. 3. Analytical measurement of chemical half-lives of monofunctional alkylators J. E. Wright, M. J. Hayes, V. Subramanyam, and A. H. Soloway pp 1700 - 1702; DOI: 10.1021/jm00222a037 |
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Synthesis of carboxyarylindoles and benzofurans as nonsteroidal antiinflammatory agents Richard C. Effland pp 1703 - 1705; DOI: 10.1021/jm00222a038 |
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Hypolipidemic activity of 5-aryl-3-methylvaleric acid derivatives John H. Dygos, Charlene M. Jett, Leland J. Chinn, and James E. Miller pp 1705 - 1708; DOI: 10.1021/jm00222a039 |
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Book Reviews pp 1708 - 1715; DOI: 10.1021/jm00222a600 |
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Additions and Corrections - Relative Concentrations of Zwitterionic and Uncharged Species in Catecholamines and the Effect of N-Substituents C. Robin Ganellin pp 1708 - 1708; DOI: 10.1021/jm00222a601 |
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Additions and Corrections - Nonenolizable Podophyllotoxin Derivatives. Walter J. Gensler, C. D. Murphy, and Marion H. Trammell pp 1708 - 1708; DOI: 10.1021/jm00222a602 |
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Additions and Corrections - Inhibition of Histidine Decarboxylase. Derivatives of Histidine. James L. Kelley, Carl A. Miller, and Helen L. White pp 1708 - 1708; DOI: 10.1021/jm00222a603 |
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Additions and Corrections - Inhibitors of Bacilus subtilis DNA Polmerase III. Structure-Activity Relationships of 6-(Phenylhydrazino)uracils. George E. Wright, and Neal C. Brown pp 1708 - 1708; DOI: 10.1021/jm00222a604 |